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FLASH GENE
Symbol BAZ1A contributors: mc/npt - updated : 24-10-2018
HGNC name bromodomain adjacent to zinc finger domain, 1A
HGNC id 960
Location 14q13.2      Physical location : 35.221.938 - 35.344.853
Synonym name
  • ATP-dependent chromatin remodeling protein
  • ATP-utilizing chromatin assembly and remodeling factor 1
  • Williams syndrome transcription factor-related chromatin-remodeling factor 180
  • CHRAC subunit ACF1
  • Synonym symbol(s) WALP1, ACF1, WCRF180, BA1A, DKFZp586E0518
    DNA
    TYPE functioning gene
    STRUCTURE 122.92 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EGLN3 14q12 egl nine homolog 3 (C. elegans) C14orf147 14q13.1 chromosome 14 open reading frame 147 LOC122585 14q13.1 similar to 60S ribosomal protein L23a C14orf11 14q13 chromosome 14 open reading frame 11 SNX6 14q12 sorting nexin 6 LOC390465 14 similar to 60S ribosomal protein L23a CFL2 14q12-q13 cofilin 2 (muscle) LOC387982 14 similar to 60S RIBOSOMAL PROTEIN L12 BAZ1A 14q12-q13 bromodomain adjacent to zinc finger domain, 1A LOC390466 14 similar to SMT3 suppressor of mif two 3 homolog 2 LOC338902 14q13.2 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) SRP54 14q12-q13 signal recognition particle 54kDa C14orf24 14q13.2 chromosome 14 open reading frame 24 C14orf10 14q12 chromosome 14 open reading frame 10 KIAA0391 14q13.1-q21.2 chromosome 14 open reading frame 10 CDC10P 14 CDC10 cell division cycle 10 homolog (S. cerevisiae) pseudogene MRP63P8 14q13.2 mitochondrial ribosomal protein 63 pseudogene 8 PSMA6 14q13 proteasome (prosome, macropain) subunit, alpha type, 6 LOC122589 14q13.2 similar to 60S acidic ribosomal protein P0 (L10E) NFKBIA 14q13 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha DNAJC8P1 14 DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene 1 LOC387983 14 LOC387983 LOC390467 14 similar to 40S RIBOSOMAL PROTEIN S3A (V-FOS TRANSFORMATION EFFECTOR PROTEIN) LOC122592 14q13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) INSM2 14q13.1 insulinoma-associated 2 LOC387984 14 similar to GARNL1 protein GARNL1 14q13.2 GTPase activating RANGAP domain-like 1 LOC341835 14q13.2 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 NUTF2P2 14 nuclear transport factor 2 pseudogene 2 BRMS1L 14q13.2 breast cancer metastasis-suppressor 1-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 6031 - 1556 - Ewing (2007)
    26 - 5935 - 1524 - Ewing (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal WAC domain
  • a receptor interacting domain (LXXLL)
  • a BAZ1 and a BAZ2 domains
  • a WAKZ motif adjacent to a (C4HC3) PHD zinc finger motif andone DDT domain
  • a C terminal bromodomain
  • HOMOLOGY
    interspecies homolog to murine Baz1a
    Homologene
    FAMILY
  • bromodomain family
  • WAL family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • mediating the assembly of core histones and DNA into periodic nucleosomes in cooperation with NAP1Lx
  • may be involved in the formation or maintenance of heterochromatin playing a critical role in developmental control
  • BAZ1A and SMARCA5, accumulate rapidly at DNA double-strand breaks and are required for DSB repair
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • of chromatin remodeling complexes CHRAC, WCRF, SNF2H
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with XRCC6 and is required for the accumulation of XRCC proteins at DNA double-strand breaks
  • CEBPB directly interacts with BAZ1A
  • functional interaction between CEBPB and SMARCA5/BAZ1A, characterized mainly by suppression of CEBPB transactivation activity in the presence of SMARCA5 and BAZ1A
  • BAZ1A and BAZ1B each recruit SMARCA5 to sites of damaged chromatin and promote survival
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS