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FLASH GENE
Symbol BAZ1A contributors: mc/npt - updated : 24-10-2018
HGNC name bromodomain adjacent to zinc finger domain, 1A
HGNC id 960
DNA
TYPE functioning gene
STRUCTURE 122.92 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 6031 - 1556 - Ewing (2007)
26 - 5935 - 1524 - Ewing (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal WAC domain
  • a receptor interacting domain (LXXLL)
  • a BAZ1 and a BAZ2 domains
  • a WAKZ motif adjacent to a (C4HC3) PHD zinc finger motif andone DDT domain
  • a C terminal bromodomain
  • HOMOLOGY
    interspecies homolog to murine Baz1a
    Homologene
    FAMILY
  • bromodomain family
  • WAL family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • mediating the assembly of core histones and DNA into periodic nucleosomes in cooperation with NAP1Lx
  • may be involved in the formation or maintenance of heterochromatin playing a critical role in developmental control
  • BAZ1A and SMARCA5, accumulate rapidly at DNA double-strand breaks and are required for DSB repair
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • of chromatin remodeling complexes CHRAC, WCRF, SNF2H
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with XRCC6 and is required for the accumulation of XRCC proteins at DNA double-strand breaks
  • CEBPB directly interacts with BAZ1A
  • functional interaction between CEBPB and SMARCA5/BAZ1A, characterized mainly by suppression of CEBPB transactivation activity in the presence of SMARCA5 and BAZ1A
  • BAZ1A and BAZ1B each recruit SMARCA5 to sites of damaged chromatin and promote survival
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS