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FLASH GENE
Symbol B3GALT5 contributors: - updated : 17-11-2003
HGNC name UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
HGNC id 920
RNA
TRANSCRIPTS type messenger
text five transcripts differing for the 5'utr and encoding an identical protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- initiation site 2760 36 310 - Ishikishi
including exons 1, 3, 4
- initiation site 2630 36 310 - Ishikishi
including exons 1', 3, 4
- initiation site - 36 310 trace amounts Ishikishi
exons 1, 2, 3, 4
- initiation site 2710 36 - trace amounts Ishikishi
exons 1, 2, 4
- - - - - - Ishikishi
exons 1, 3, 4 intron IV3
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 stomach    
Endocrinepancreas    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines adenocarcinoma cell lines (Colo205)
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text type II membrane protein
basic FUNCTION
  • mucin glycosylation with a preference for the core 3-O-glycosylation
  • catalyzing by N-acetylglucosamine-beta-1,3-galactosyltransferase (beta-3-GalT), which transfers a galactose to an N-acetylglucosamine with a beta-1,3-linkage, resulting in the synthesis of a type 1 Lewis chain.
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • most probable candidate responsible for the synthesis of the type I Lewis antigen in gastrointestinal and pancreatic epithelia and tumor cells derived thereform. Key enzyme that determines the amount of type I Lewis antigen
  • including the sialyl Lewis a antigen
  • PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by TCF1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS