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FLASH GENE
Symbol AURKB contributors: mct/shn - updated : 22-09-2016
HGNC name aurora kinase B
HGNC id 11390
Location 17p13.1      Physical location : 8.108.049 - 8.113.883
Synonym name
  • ARK-2
  • STK-1
  • aurora kinase B-Sv1
  • aurora kinase B-Sv2
  • aurora- and Ipl1-like midbody-associated protein 1
  • aurora-1
  • aurora-B
  • aurora-related kinase 2
  • aurora/IPL1-related kinase 2
  • serine/threonine kinase 12
  • serine/threonine-protein kinase 12
  • serine/threonine-protein kinase aurora-B
  • Synonym symbol(s) Aik2, IPL1, AurB, AIM-1, ARK2, STK5, STK12, AIM1, aurkb-sv1, aurkb-sv2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 5.84 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter activity was upregulated during M phase, and its cell cycle-dependent element (CDE) and cell cycle-gene homology region (CHR) upstream of the transcription initiation sites regulated the cell cycle-dependent promoter activity
    MAPPING cloned Y linked N status provisional
    Map pter - D17S1353 - D17S1796 - AURKB - D17S1812 - D17S1805 - cen
    Physical map
    LOC92162 17p13.2 similar to RIKEN cDNA 2600017H02 MGC14151 17p13.2 hypothetical protein MGC14151 FLJ32499 17p13.2 hypothetical protein FLJ32499 LOC388331 17 LOC388331 KCNAB3 17p13.1 potassium voltage-gated channel, shaker-related subfamily, beta member 3 TRAPPC1 17p13.1 trafficking protein particle complex 1 LIP8 17p13.2 LYST-interacting protein LIP8 GUCY2D 17p13.1 guanylate cyclase 2D, membrane (retina-specific) ALOX15B 17p13.1 arachidonate 15-lipoxygenase, second type LOC388332 17 similar to Gag protein ALOX12B 17p13.1 arachidonate 12-lipoxygenase, 12R type ALOXE3 17p13.1 arachidonate lipoxygenase 3 HES7 17p13.1 hairy and enhancer of split 7 (Drosophila) PER1 17p13.1-p12 period homolog 1 (Drosophila) VAMP2 17p13.1-p12 vesicle-associated membrane protein 2 (synaptobrevin 2) MGC10744 17p13.1 hypothetical protein MGC10744 FLJ20014 17p13.1 hypothetical protein FLJ20014 AURKB 17p13.1 aurora kinase B FLJ34790 17p13.1 hypothetical protein FLJ34790 FLJ22170 17p13.1 hypothetical protein FLJ22170 PFAS 17p13 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) RANGNRF 17p13 RAN guanine nucleotide release factor ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4 LOC124751 17p13.1 hypothetical protein LOC124751 RPL26 17p13 ribosomal protein L26 LOC390761 17 similar to RIKEN cDNA 9930039A11 gene NDEL1 17p13.1 nudE nuclear distribution gene E homolog like 1 (A. nidulans) MYH10 17p13.1 myosin, heavy polypeptide 10, non-muscle
    regionally located region containing tumor related genes such as p53, CRK and ABR
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1253 39.2 344 - 1998 9931403
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver   highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eleven conserved regions characteristic of a protein kinase catalytic domain at the C terminus
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Ipl1
    homolog to Drosophila aurora
    ortholog to Aurkb, Rattus norvegicus
    ortholog to aurkb, Danio rerio
    ortholog to AURKB, Pan troglodytes
    ortholog to Aurkb, Mus musculus
    Homologene
    FAMILY
  • Aurora family kinases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • localized to the midbody
  • localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers
  • basic FUNCTION
  • serine/threonine kinase 12, required for mitotic chromosome alignement and segregation processes
  • involved in protein amino acid phosphorylation
  • mitotic histone H3 kinase, required for mitotic chromatin-induced phosphorylation of STMN1
  • regulating kinetochore-microtubule attachment during both meiotic divisions
  • important serine/threonine kinase required for chromosome segregation and cytokinesis
  • may regulate cleavage furrow-specific phosphorylation and segregation of type III IFs coordinatedly with Rho-kinase during cytokinesis
  • may regulate cleavage furrow-specific phosphorylation and segregation of type III IFs coordinatedly with Rho-kinase during cytokinesis
  • regulates, in association whith AURKA, kinetochore function in human cells
  • can act as a regulator of the epigenetic status of differentiated postmitotic cells
  • required for chromosome segregation and the progression of cytokinesis during the cell cycle
  • playing a role in epigenetic marking of silent chromatin during cell differentiation
  • having a role in marking silent chromatin independently of the cell cycle
  • cycle-regulatory serine-threonine kinases implicated in the function of the centrosomes, kinetechores, chromosome dynamics, and cytokinesis
  • having specialized functions in mammalian spermatogenesis
  • participates to regulate the assembly of nucleolar RNA-processing machinery and the RNA methyltransferase activity of NSUN2 via phosphorylation at Ser139 during mitosis
  • regulates the association of condensin I, but not the interaction of condensin II with chromatin and contributes to chromosome rigidity and segregation by promoting the binding of condensin I to chromatin
  • involved in proliferation, and aggressiveness of prolactin pituitary tumors
  • during mitosis, inhibits nucleus reformation by preventing chromosome decondensation and formation of the nuclear envelope membrane
  • plays a critical role in correcting aberrant kinetochore-microtubule attachments by phosphorylating key substrates at the kinetochore and promoting turnover of kinetochore microtubules
  • AURKB, is essential for recruiting outer kinetochore components such as NDC80 components and CENPE for functional kinetochore assembly
  • through phosphorylation of CENPE at T422, regulates the intrinsic motor properties of CENPE and disrupts the binding of the opposing phosphatase PPP1CC to CENPE, thereby establishing a bistable phosphoswitch for regulation of CENPE
  • can regulate the cleavage of furrow-specific vimentin phosphorylation and then control vimentin filament segregation during the cytokinetic process
  • might contribute to spindle checkpoint signalling independently of error correction
  • is potentially not essential for the spindle assembly checkpoint
  • CDK1 and AURKB cooperatively modulate microtubule dynamics and AURKB-dependent phosphorylation of INCENP controls spindle function by excluding the CPC from spindle regions engaged in microtubule polymerization
  • functions in chromosome segregation and cleavage of polar spindle microtubules
  • might function in the regulation of cellular senescence of primary cells via a TP53-dependent pathway
  • AURKB functions to correct improper kinetochore-microtubule attachments and alert the spindle checkpoint to the presence of misaligned chromosomes
  • AURKB and KIF2A control microtubule length for assembly of a functional central spindle during anaphase
  • RNF2, AURKB have essential roles in regulating transcriptionally active genes in quiescent lymphocytes
  • AURKB on the interchromatid axis is likely not needed for spindle assembly checkpoint (SAC) activation
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    text cytokinesis
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with protein serine/threonine phosphatase type 1 (PP1) or PP2A
  • component of error correction
  • interacts with BIRC5, borealin (CDCA8) and INCENP to form the chromosomal passenger complex (CPC), which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis
  • Aurora B represses CDKN1A, preventing delayed DNA replication, CDK inhibition and premature mitotic exit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with histone H3 and centromeres at the times when histone H3 and CENP-A are phosphorylated in early G2
  • ras GTPase-activating protein, RasGAP
  • baculoviral IAP repeat-containing 5, BIRC5
  • phosphorylates MgcRacGAP
  • inner centromere protein, INCENP
  • might undergo degradation by binding to PSMA3 in a proteasome-dependent manner during mitosis
  • regulates of mitotic centromere-associated kinesin (MCAK) activity and its localization at the centromere and kinetochore
  • transforming, acidic coiled-coil containing protein 1, TACC1
  • mitotic kinesin-like protein 2, MKlp2
  • Septin1, SEPT1
  • phosphorylates Histone H3
  • ecotropic viral integration site 5, EVI5
  • AURKB activity is required for the accumulation of tension-sensitive mitotic-checkpoint components, such as ZW10 and KNTC1, in order to maintain mitotic-checkpoint arrest
  • end-binding protein 1, EB1
  • DSN1 is a cognate substrate of AURKB, and the phosphorylation sites were mapped to Ser-100 and Ser-109
  • BARD1beta
  • Flotillin-1, FLOT1
  • SGOL2 is an hitherto unknown crucial cellular substrate of Aurora B in mammalian cells
  • interrelationship between MLF1IP and NDC80 in the stabilization of kinetochore-microtubule attachment, and this interaction is under Aurora-B modulation
  • AURKB kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between AURKB and HASPIN functions in mitosis
  • ZWINT is a novel AURKB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
  • AURKB phosphorylation antagonizes the interaction between the SKA complex and the KMN network (named according to the acronym for KNL1, MIS12, and NDC80), thereby controlling SKA recruitment to kinetochore (KT) and stabilization of KT-MT attachments
  • CHMP4C functioned in the Aurora B–dependent abscission checkpoint to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage
  • target of HASPIN inhibitor possibly HASPIN itself, may further contribute to spindle assembly checkpoint (SAC) signaling downstream of AURKB
  • AURKB, which regulates KIF23 localization at the midzone, is delocalized from the spindle midzone and the midbody but not from the metaphase chromosomes upon SRC expression
  • AURKB ensures that suppression of microtubule dynamic instability by KIF4A is restricted to a specific subset of microtubules and thereby contributes to central spindle size control in anaphase
  • AURKB and CDK1 mediate WAPL activation and release of acetylated cohesin from chromosomes by phosphorylating CDC5A
  • novel role for AURKB-NDC80-TTK signaling axis in governing accurate chromosome segregation in mitosis
  • TERF1 is required for the centromeric function of AURKB, which ensures proper chromosome segregation
  • CHEK2 stabilizes TTK and phosphorylates AURKB-serine 331 to prevent mitotic exit when most kinetochores are unattached
  • HASPIN kinase plays a key role in maintaining the slowly exchanging centromere CDCA8pool, while AURKB play minimal role in maintaining chromosomal passenger complex (CPC) localization once cells are in mitosis
  • targeting AURKB to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
  • MAD1L1 plays a minor role in influencing the MAD2L1-dependent regulation of AURKB suggesting that the effects of MAD2L1 on AURKB are independent of the spindle checkpoint complex
  • AURKA promotes the establishment of spindle assembly checkpoint by priming the HASPIN-AURKB feedback loop in late G2 phase
  • cell & other
    REGULATION
    activated by okaidic acid
    telophase disc-60kD (TD-60) and microtubules
    BIRC5 (reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B)
    induced by BCR-ABL inducing expression of AURKA and AURKB at least in part via AKT1
    inhibited by PARP1 (contributing to the physiological response to DNA damage)
    Phosphorylated by LATS1 that phosphorylate Aurora B (AURKB)
    Other dependent of INCENP
    regulated by cell cycle-dependent element (CDE) and cell cycle-gene homology region (CHR) upstream of the transcription initiation sites
    stimulates by end-binding protein 1, EB1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in tumors
    tumoral     --over  
    in prostate carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential therapeutic target for prostate carcinoma
    ANIMAL & CELL MODELS