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FLASH GENE
Symbol ATP1B3 contributors: - updated : 03-07-2007
HGNC name ATPase, Na+/K+ transporting, beta 3 polypeptide
HGNC id 806
Location 3q22-q23      Physical location : 141.595.469 - 141.645.382
Synonym name
  • Na+/K+ -ATPase beta 3 subunit
  • Na, K-ATPase beta-3 polypeptide
  • sodium/potassium-dependent ATPase beta-3 subunit
  • Synonym symbol(s) CD298, ATPB-3, FLJ29027
    EC.number 3.6.3.9
    DNA
    TYPE functioning gene
    STRUCTURE 50.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2 LOC389153 3 LOC389153 LOC391585 3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) RNF7 3q22-q24 ring finger protein 7 GPRK7 3q21-q24 G protein-coupled receptor kinase 7 ATP1B3 3q22-q23 ATPase, Na+/K+ transporting, beta 3 polypeptide TFDP2 3q23 transcription factor Dp-2 (E2F dimerization partner 2) MGC40579 3q23 hypothetical protein MGC40579 SEP1 3q23 strand-exchange protein 1 ATR 3q22-q24 ataxia telangiectasia and Rad3 related PLS1 3q23 plastin 1 (I isoform) TRPC1 3q22-q24 transient receptor potential cation channel, subfamily C, member 1 PCOLCE2 3q21-q24 procollagen C-endopeptidase enhancer 2 PAQR9 3q23 progestin and adipoQ receptor family member IX SR140 3q23-q24 progestin and adipoQ receptor family member IX LOC389154 3 LOC389154 CHST2 3q24 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 PBXP1 3q22-q23 pre-B-cell leukemia transcription factor pseudogene 1 SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 1600 - 279 widely Malik
    - - - 1800 - 279 widely Malik
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouth   highly
     pharynx   highly
     stomach   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    intraspecies homolog to ATP1B and ATP4B,structural
    Homologene
    FAMILY Na+/K+ and H+/K+ ATPases beta chain proteins family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 2 membrane protein
    basic FUNCTION
  • osmotic balance and cell volume stability
  • catalyzing the hydrolysis of ATP coupled
  • with the exchange of Na(+) and K(+) ions across the plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+, K+ pump
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ATP1A3 and maybe others
  • two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein binding to ATP1A3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS