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FLASH GENE
Symbol ATP1B3 contributors: - updated : 03-07-2007
HGNC name ATPase, Na+/K+ transporting, beta 3 polypeptide
HGNC id 806
Location 3q22-q23      Physical location : 141.595.469 - 141.645.382
Synonym name
  • Na+/K+ -ATPase beta 3 subunit
  • Na, K-ATPase beta-3 polypeptide
  • sodium/potassium-dependent ATPase beta-3 subunit
    • Synonym symbol(s) CD298, ATPB-3, FLJ29027
    EC.number 3.6.3.9
    DNA
    TYPE functioning gene
    STRUCTURE 50.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 1600 - 279 widely Malik
    - - - 1800 - 279 widely Malik
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouth   highly
     pharynx   highly
     stomach   highly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    intraspecies homolog to ATP1B and ATP4B,structural
    Homologene
    FAMILY Na+/K+ and H+/K+ ATPases beta chain proteins family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 2 membrane protein
    basic FUNCTION
  • osmotic balance and cell volume stability
  • catalyzing the hydrolysis of ATP coupled
    • with the exchange of Na(+) and K(+) ions across the plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+, K+ pump
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ATP1A3 and maybe others
  • two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein binding to ATP1A3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS