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FLASH GENE
Symbol ATP1B2 contributors: mct - updated : 09-03-2010
HGNC name ATPase, Na+/K+ transporting, beta 2 polypeptide
HGNC id 805
Location 17p13.1      Physical location : 7.554.253 - 7.561.089
Synonym name
  • adhesion molecular on glia
  • sodium/potassium-transporting ATPase beta-2 chain
  • Na+/K+ -ATPase beta 2 subunit
  • Synonym symbol(s) AMOG
    EC.number 3.6.3.9
    DNA
    TYPE functioning gene
    STRUCTURE 6.84 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site   transcription factor
    motif repetitive sequence   ALU
    text structure
  • Sp1 site,Alu in 3'utr
  • MAPPING cloned Y linked N status confirmed
    Map pter - TNK1 - NEUROD2 - CHRNB1 - FGF11 - POLR2A - TNFSF13 - TNFSF12 - CD68 - EIF4A1 - FXR2 - SHBG - TP53 - ATP1B2 - ALOX12 - VAMP2 - CHD3 - KDM6B - cen
    Authors Cousin (00)
    Physical map
    ZBTB4 17p13.2 zinc finger and BTB domain containing 4 POLR2A 17p13.1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa TNFSF12 17p13.1 tumor necrosis factor (ligand) superfamily, member 12 TNFSF13 17p13.1 tumor necrosis factor (ligand) superfamily, member 13 SENP3 17p13 tumor necrosis factor (ligand) superfamily, member 13 EIF4A1 17p13.1 eukaryotic translation initiation factor 4A, isoform 1 CD68 17p13.1 CD68 antigen MPDU1 17p13.1-p12 mannose-P-dolichol utilization defect 1 SOX15 17p12.3 SRY (sex determining region Y)-box 15 FXR2 17p13.1 fragile X mental retardation, autosomal homolog 2 SAT2 17p13.2 spermidine/spermine N1-acetyltransferase 2 SHBG 17p13.1 sex hormone-binding globulin ATP1B2 17p13.1 ATPase, Na+/K+ transporting, beta 2 polypeptide TP53 17p13.1 tumor protein p53 (Li-Fraumeni syndrome) FLJ10385 17p13.2 hypothetical protein FLJ10385 EFNB3 17p13.1-p11.2 ephrin-B3 LOC284158 17p13.2 similar to KIAA1503 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3350 - 290 - Hsieh 1990
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrainhindbraincerebellum  
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Atp1b2 (97.2pc)
    homolog to rattus Atp1b2 (97.9pc)
    Homologene
    FAMILY
  • X(+)/potassium ATPases subunit beta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • part of the active enzyme responsible for establishing and maintaining the electrochemical gradients of Na and K ions accross the plasma membrane
  • exact role of the beta-subunit is unknown
  • may regulate, through the assembly with alpha/beta heterodimers, the number of sodium pumps transported to plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+, K+ pump
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ATP1A3 and maybe others
  • non catalytic component of the active enzyme, composed at least of the alpha, beta and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • binding to ATP1A3
  • binding to ATP1AX
  • ATP1A3 and ATP1B2 are binding partners of retinoschisin (predominant role of Na/K-ATPase in anchoring retinoschisin to retinal cell surfaces)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly lower in secondary and primary glioblastomas than in diffuse astrocytomas grade II, due to promoter hypermethylation (Van den Boom 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS