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FLASH GENE
Symbol ATP1B2 contributors: mct - updated : 09-03-2010
HGNC name ATPase, Na+/K+ transporting, beta 2 polypeptide
HGNC id 805
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Atp1b2 (97.2pc)
homolog to rattus Atp1b2 (97.9pc)
Homologene
FAMILY
  • X(+)/potassium ATPases subunit beta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • part of the active enzyme responsible for establishing and maintaining the electrochemical gradients of Na and K ions accross the plasma membrane
  • exact role of the beta-subunit is unknown
  • may regulate, through the assembly with alpha/beta heterodimers, the number of sodium pumps transported to plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+, K+ pump
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ATP1A3 and maybe others
  • non catalytic component of the active enzyme, composed at least of the alpha, beta and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • binding to ATP1A3
  • binding to ATP1AX
  • ATP1A3 and ATP1B2 are binding partners of retinoschisin (predominant role of Na/K-ATPase in anchoring retinoschisin to retinal cell surfaces)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly lower in secondary and primary glioblastomas than in diffuse astrocytomas grade II, due to promoter hypermethylation (Van den Boom 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS