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Symbol ASPG contributors: npt/mct - updated : 19-11-2021
HGNC name asparaginase homolog (S. cerevisiae)
HGNC id 20123
Location 14q32.33      Physical location : 104.552.047 - 104.578.925
Synonym name
  • chromosome 14 open reading frame 76
  • 60 kDa lysophospholipase
  • platelet-activating factor acetylhydrolase
    • Synonym symbol(s) C14orf76, GPA/WT, LYSOLP
    EC.number 3.1.1.5, 3.1.1.47, 3.5.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 26.88 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1844 - 579 - 2012 22861376
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two domains: an N-terminal domain that is homologous to the E. coli cytoplasmic-type I l-asparaginase
  • a C-terminal ankyrin repeat-like domain
    • HOMOLOGY
    Homologene
    FAMILY
  • asparaginase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • has indeed a lysophospholipase activity and affects metabolic functions related to cell proliferation and regulation of membrane channels
  • may represent a new player in the regulation of SCNN1A and SGK1-dependent signaling
  • specific role of this enzyme as an interacting partner of the serum- and glucocorticoid-induced serine/threonine protein kinase SGK1, an enzyme involved in various cell proliferation pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction between SGK1 and ASPG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS