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FLASH GENE
Symbol ASPG contributors: npt/mct - updated : 19-11-2021
HGNC name asparaginase homolog (S. cerevisiae)
HGNC id 20123
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two domains: an N-terminal domain that is homologous to the E. coli cytoplasmic-type I l-asparaginase
  • a C-terminal ankyrin repeat-like domain
    • HOMOLOGY
    Homologene
    FAMILY
  • asparaginase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • has indeed a lysophospholipase activity and affects metabolic functions related to cell proliferation and regulation of membrane channels
  • may represent a new player in the regulation of SCNN1A and SGK1-dependent signaling
  • specific role of this enzyme as an interacting partner of the serum- and glucocorticoid-induced serine/threonine protein kinase SGK1, an enzyme involved in various cell proliferation pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction between SGK1 and ASPG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS