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FLASH GENE
Symbol ASGR1 contributors: mct - updated : 06-04-2013
HGNC name asialoglycoprotein receptor 1
HGNC id 742
Location 17p13.1      Physical location : 7.076.751 - 7.082.883
Synonym name hepatic lectin H1
Synonym symbol(s) ASGPR, ASGPR1, CLEC4H1, HL-1
DNA
TYPE functioning gene
STRUCTURE 6.13 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ALOX12P2 17p13.1 arachidonate 12-lipoxygenase pseudogene 2 ALOX12 17p13.1 arachidonate 12-lipoxygenase LOC388328 17 LOC388328 MGC49942 17p13.2 hypothetical protein MGC49942 BCL6B 17p13.1 B-cell CLL/lymphoma 6, member B (zinc finger protein) LOC201232 SLC16A11 17p13.2 solute carrier family 16 (monocarboxylic acid transporters), member 11 CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 ASGR2 17p13.1 asialoglycoprotein receptor 2 ASGR1 17p12 asialoglycoprotein receptor 1 DLG4 17p13.1 discs, large (Drosophila) homolog 4 ACADVL 17p13.1 acyl-Coenzyme A dehydrogenase, very long chain DVL2 17p13.2 dishevelled, dsh homolog 2 (Drosophila) MGC2941 17p13.2 hypothetical protein MGC2941 GABARAP 17p13.1 GABA(A) receptor-associated protein DULLARD 17p13 dullard homolog (Xenopus laevis) DERP6 17p13.2 S-phase 2 protein CLDN7 17p13.1 claudin 7 SLC2A4 17p13.1 solute carrier family 2 (facilitated glucose transporter), member 4 YBX2 17p11.2-p13.1 germ cell specific Y-box binding protein EIF5A 17p13-p12 eukaryotic translation initiation factor 5A GPS2 17p13 G protein pathway suppressor 2 LOC390760 17 similar to RIKEN cDNA 2810408A11 CENTB1 17p13.2 centaurin, beta 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1402 - 252 - 2010 20886072
  • ASGPR H1b
  • protein lacking the transmembrane domain
  • its expression is reduced in liver tissues from patients with viral hepatitis
  • 9 - 1519 - 291 - 2010 20886072
  • ASGPR H1a
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly Homo sapiensAdult
     stomach    
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiensAdult
    Digestivehepatocyte Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-type lectin domain
  • HOMOLOGY
    interspecies homolog to murine Asgr1
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II membrane protein
    basic FUNCTION
  • transporting the glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates
  • mediating the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed
  • is a novel important factor that responds to endogenous lectins in the tumor microenvironment to promote cancer metastasis by activating the EGFR-ERK pathway through interactions with counter-receptors on cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to galactose-terminated glycoproteins
  • with LASS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of the hepatic asialoglycoprotein receptor (Asgpr) in mice severely reduces the frequency of spontaneous lung metastasis after intrahepatic implantation of murine Lewis lung carcinoma (3LL) cell