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FLASH GENE
Symbol ASGR1 contributors: mct - updated : 06-04-2013
HGNC name asialoglycoprotein receptor 1
HGNC id 742
Location 17p13.1      Physical location : 7.076.751 - 7.082.883
Synonym name hepatic lectin H1
Synonym symbol(s) ASGPR, ASGPR1, CLEC4H1, HL-1
DNA
TYPE functioning gene
STRUCTURE 6.13 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1402 - 252 - 2010 20886072
  • ASGPR H1b
  • protein lacking the transmembrane domain
  • its expression is reduced in liver tissues from patients with viral hepatitis
  • 9 - 1519 - 291 - 2010 20886072
  • ASGPR H1a
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   predominantly Homo sapiensAdult
     stomach    
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiensAdult
    Digestivehepatocyte Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-type lectin domain
  • HOMOLOGY
    interspecies homolog to murine Asgr1
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II membrane protein
    basic FUNCTION
  • transporting the glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates
  • mediating the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed
  • is a novel important factor that responds to endogenous lectins in the tumor microenvironment to promote cancer metastasis by activating the EGFR-ERK pathway through interactions with counter-receptors on cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to galactose-terminated glycoproteins
  • with LASS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of the hepatic asialoglycoprotein receptor (Asgpr) in mice severely reduces the frequency of spontaneous lung metastasis after intrahepatic implantation of murine Lewis lung carcinoma (3LL) cell