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FLASH GENE
Symbol ASGR1 contributors: mct - updated : 06-04-2013
HGNC name asialoglycoprotein receptor 1
HGNC id 742
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-type lectin domain
  • HOMOLOGY
    interspecies homolog to murine Asgr1
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II membrane protein
    basic FUNCTION
  • transporting the glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates
  • mediating the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed
  • is a novel important factor that responds to endogenous lectins in the tumor microenvironment to promote cancer metastasis by activating the EGFR-ERK pathway through interactions with counter-receptors on cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to galactose-terminated glycoproteins
  • with LASS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of the hepatic asialoglycoprotein receptor (Asgpr) in mice severely reduces the frequency of spontaneous lung metastasis after intrahepatic implantation of murine Lewis lung carcinoma (3LL) cell