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FLASH GENE

Symbol

ARNT2

contributors: mct/npt - updated : 13-11-2018

HGNC name	aryl-hydrocarbon receptor nuclear translocator 2
HGNC id	16876

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q24      Physical location : 80.696.691 - 80.890.272
Synonym name	ARNT protein 2
	similar to Rat Arnt2
Synonym symbol(s)	KIAA0307, bHLHe1

DNA

TYPE	functioning gene
STRUCTURE	193.00 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

at least 19 exons

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ARNT2 19 - 6576 78 717 - Friedman (2007)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Nervous brain       highly   nerve       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal basic helix-loop-helix (HLH) motif juxtaposed to a PAS (Per-Arnt-Sim) domain
	a cysteine rich region
	a glutamine-rich region at the C-terminal end (Yamanaka 2010)

HOMOLOGY

interspecies

homolog to rattus ARNT2

Homologene

FAMILY

PAS superfamily

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	hypoxic response in the CNS
	with its cofactor SIM1, are required for expression of POU3F2 during hypothalamic development (Yamanaka 2010)
	ARNT2 and SIM1 are required to determine the lateral position of neuroendocrine and dopaminergic (DA) longitudinal axons en route to the spinal cord
	ARNT2 and SIM1 transcription factors contribute to proper positioning of Hypothalamic projections into the spinal cord (HTS)longitudinal axon tracts

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	dimerization partner of SIM1 for the development of hypothalamus

PATHWAY

metabolism

signaling

a component	complexing with HIF1A
	forms a protein complex with SIM1 in hypothalamus (Yamanaka 2010)

INTERACTION

DNA

RNA

small molecule

protein	interacting with NDN (N-terminal 115 residues of NDN are sufficient for interaction with the bHLH domains of ARNT2 or HIF1alpha but not for transcriptional repression)
	MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AHR, HIF1A and ARNT

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS