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FLASH GENE
Symbol ARNT2 contributors: mct/npt - updated : 13-11-2018
HGNC name aryl-hydrocarbon receptor nuclear translocator 2
HGNC id 16876
Location 15q24      Physical location : 80.696.691 - 80.890.272
Synonym name
  • ARNT protein 2
  • similar to Rat Arnt2
  • Synonym symbol(s) KIAA0307, bHLHe1
    DNA
    TYPE functioning gene
    STRUCTURE 193.00 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure at least 19 exons
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390612 15 similar to ribosomal protein L18; 60S ribosomal protein L18 LOC388142 15 LOC388142 LOC390613 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) ADAMTS7 15pter-qter a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 LOC390614 15 similar to cDNA sequence BC053073; G-protein coupled receptor SALPR; somatostatin and angiotensin-like peptide receptor LOC388143 15 similar to 60S ribosomal protein L21 MORF4L1 15q24 mortality factor 4 like 1 CTSH 15q24-q25 cathepsin H RASGRF1 15q24 Ras protein-specific guanine nucleotide-releasing factor 1 LOC390615 15 similar to HNRPC protein LOC390616 15 similar to RIKEN cDNA 6430502M16 gene P24B 15q24-q25 integral type I protein KIAA1024 15q24.2 KIAA1024 protein LOC390617 15 similar to Transcription factor DP-1 (E2F dimerization partner 1) (DRTF1-polypeptide-1) (DRTF1) LOC390618 15 similar to ribosomal protein L7-like 1 LOC390619 15 similar to zinc finger, FYVE domain containing 1 isoform 1; phosphoinositide-binding protein SR3; tandem FYVE fingers-1 protein; zinc finger protein, subfamily 2A, member 1; double FYVE-containing protein 1 MTHFS 15q24 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) LOC283687 15q24.3 hypothetical protein LOC283687 LOC390620 15 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) BCL2A1 15q24.3 BCL2-related protein A1 HSPC073 15q24.3 HSPC073 protein AWP1 15q24 HSPC073 protein FAH 15q23-q25 fumarylacetoacetate hydrolase (fumarylacetoacetase) LOC388144 15 LOC388144 ARNT2 15q24-q25 aryl-hydrocarbon receptor nuclear translocator 2 LOC58489 15q24.3 hypothetical protein from EUROIMAGE 588495 KIAA1199 15q KIAA1199 protein MESDC2 15q13 mesoderm development candidate 2 MESDC1 15q13 mesoderm development candidate 1 FLJ38615 15q24.3 hypothetical protein FLJ38615 IL16 15q26.3 interleukin 16 (lymphocyte chemoattractant factor) STARD5 15q26 START domain containing 5 TMC3 15q24.3 transmembrane channel-like 3 LOC390621 15 similar to protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) DKFZp434J0617 15q25.1 hypothetical protein DKFZp434J0617 FLJ13119 15q25.1 hypothetical protein FLJ13119
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 6576 78 717 - Friedman (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbrain   highly
     nerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal basic helix-loop-helix (HLH) motif juxtaposed to a PAS (Per-Arnt-Sim) domain
  • a cysteine rich region
  • a glutamine-rich region at the C-terminal end (Yamanaka 2010)
  • HOMOLOGY
    interspecies homolog to rattus ARNT2
    Homologene
    FAMILY
  • PAS superfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • hypoxic response in the CNS
  • with its cofactor SIM1, are required for expression of POU3F2 during hypothalamic development (Yamanaka 2010)
  • ARNT2 and SIM1 are required to determine the lateral position of neuroendocrine and dopaminergic (DA) longitudinal axons en route to the spinal cord
  • ARNT2 and SIM1 transcription factors contribute to proper positioning of Hypothalamic projections into the spinal cord (HTS)longitudinal axon tracts
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text dimerization partner of SIM1 for the development of hypothalamus
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HIF1A
  • forms a protein complex with SIM1 in hypothalamus (Yamanaka 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NDN (N-terminal 115 residues of NDN are sufficient for interaction with the bHLH domains of ARNT2 or HIF1alpha but not for transcriptional repression)
  • MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AHR, HIF1A and ARNT
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS