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FLASH GENE
Symbol ARNT2 contributors: mct/npt - updated : 13-11-2018
HGNC name aryl-hydrocarbon receptor nuclear translocator 2
HGNC id 16876
DNA
TYPE functioning gene
STRUCTURE 193.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure at least 19 exons
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 6576 78 717 - Friedman (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Nervousbrain   highly
 nerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal basic helix-loop-helix (HLH) motif juxtaposed to a PAS (Per-Arnt-Sim) domain
  • a cysteine rich region
  • a glutamine-rich region at the C-terminal end (Yamanaka 2010)
  • HOMOLOGY
    interspecies homolog to rattus ARNT2
    Homologene
    FAMILY
  • PAS superfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • hypoxic response in the CNS
  • with its cofactor SIM1, are required for expression of POU3F2 during hypothalamic development (Yamanaka 2010)
  • ARNT2 and SIM1 are required to determine the lateral position of neuroendocrine and dopaminergic (DA) longitudinal axons en route to the spinal cord
  • ARNT2 and SIM1 transcription factors contribute to proper positioning of Hypothalamic projections into the spinal cord (HTS)longitudinal axon tracts
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text dimerization partner of SIM1 for the development of hypothalamus
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HIF1A
  • forms a protein complex with SIM1 in hypothalamus (Yamanaka 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NDN (N-terminal 115 residues of NDN are sufficient for interaction with the bHLH domains of ARNT2 or HIF1alpha but not for transcriptional repression)
  • MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AHR, HIF1A and ARNT
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS