Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ARL2BP

contributors: mct/npt - updated : 07-12-2020

HGNC name	ADP-ribosylation factor-like 2 binding protein
HGNC id	17146

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	RPSI retinitis pigmentosa with situs inversus (or not)
Location	16q13      Physical location : 57.279.037 - 57.287.545
Synonym name	Arf-like 2 binding protein BART1
	binder of Arl Two
Synonym symbol(s)	BART, BART1

DNA

TYPE	functioning gene
STRUCTURE	8.51 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012106 6 - 2100 NP_036238 18.7 163 - 1999 10488091

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, fetal spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

secondary structure

forms a novel fold composed of six alpha-helices that form three interlocking "L" shapes

HOMOLOGY

Homologene

FAMILY

ARL2BP family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle

basic FUNCTION	could be acting to tether ARL2 to the mitochondrial membrane via its interaction with adenine nucleotide transporter isoform 1
	centrosome-associated protein in a variety of mammalian cell lines
	plays an essential role in the nuclear retention of STAT3 through interaction with ARL2
	plays a role in inhibiting cell invasion by regulating the activity of the Rho GTPase protein RHOA in pancreatic cancer cells
	increases active RHOA by inhibiting ARL2 function, which in turn inhibits invasiveness of cancer cells
	regulates actin-cytoskeleton rearrangements at membrane ruffles through modulation of the activity of RAC1, which, in turn, inhibits pancreatic cancer cell invasion
	role for ARL2BP and ARL2 in primary cilia function and that this role is essential for normal photoreceptor maintenance and function
	plays an essential role in the retina, and show that this role is mediated in part by the ARL2BP-ARL2 interaction
	is necessary for photoreceptor ciliary doublet formation and axoneme elongation, which is required for OS morphogenesis and vision
	is required for the structural maintenance of cilia as well as of the sperm flagellum

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interact and act as a nuclear retention factor for transcription factor STAT3
	STAT-binding partner (essential for the transcriptional activity and nuclear retention of STAT3)
	G3BP1 binds to and degrades its mRNA
	G3BP1 binds and degrades the mRNA of ARL2BP inhibiting retroperitoneal invasion and hepatic metastasis of pancreatic cancer cells
	binds the same site in ARL2 as do the effectors UNC119 and PDE6D37 and would compete for binding to the activated GTPase
	interaction between ARL2BP and ARL2 is important for recruitment or anchoring of ARL2BP at the basal body

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RPSI

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function leads to syndromic ciliopathy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS