SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,interspace
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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basic FUNCTION
| could be acting to tether ARL2 to the mitochondrial membrane via its interaction with adenine nucleotide transporter isoform 1 |
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centrosome-associated protein in a variety of mammalian cell lines |
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plays an essential role in the nuclear retention of STAT3 through interaction with ARL2 |
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plays a role in inhibiting cell invasion by regulating the activity of the Rho GTPase protein RHOA in pancreatic cancer cells |
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increases active RHOA by inhibiting ARL2 function, which in turn inhibits invasiveness of cancer cells |
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regulates actin-cytoskeleton rearrangements at membrane ruffles through modulation of the activity of RAC1, which, in turn, inhibits pancreatic cancer cell invasion |
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role for ARL2BP and ARL2 in primary cilia function and that this role is essential for normal photoreceptor maintenance and function |
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plays an essential role in the retina, and show that this role is mediated in part by the ARL2BP-ARL2 interaction |
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is necessary for photoreceptor ciliary doublet formation and axoneme elongation, which is required for OS morphogenesis and vision |
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is required for the structural maintenance of cilia as well as of the sperm flagellum |