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FLASH GENE

Symbol

ARL11

contributors: CTU/npt - updated : 01/10/2008

HGNC name	ADP-ribosylation factor-like 11
HGNC id	24046

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q14.3      Physical location : 50.202.434 - 50.208.008
Synonym name	ADP-ribosylation factor-like tumor suppressor protein 1
Synonym symbol(s)	ARLTS1, MGC17429, FLJ33930

DNA

TYPE	functioning gene
STRUCTURE	5.11 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138450 2 - 3294 NP_612459 21.4 196 - Siltanen (2008)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Arl11

Homologene

FAMILY	small GTPase superfamily
	ADP-ribosylation factors (ARF) family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	acting as a tumor suppressor
	playing a role in apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in lung cancer

Susceptibility

to general familial cancer, familial CLL, familial breast cancer

Variant & Polymorphism other	G446A increases the risk of familial cancer, Cys148Arg and trp149stop familial breast cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS