Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARL11 contributors: CTU/npt - updated : 01/10/2008
HGNC name ADP-ribosylation factor-like 11
HGNC id 24046
DNA
TYPE functioning gene
STRUCTURE 5.11 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3294 21.4 196 - Siltanen (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Arl11
Homologene
FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a tumor suppressor
  • playing a role in apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in lung cancer
    Susceptibility to general familial cancer, familial CLL, familial breast cancer
    Variant & Polymorphism other G446A increases the risk of familial cancer, Cys148Arg and trp149stop familial breast cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS