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FLASH GENE

Symbol

ARID3A

contributors: mct - updated : 03-09-2016

HGNC name	AT rich interactive domain 3A (BRIGHT-like)
HGNC id	3031

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 926.036 - 972.791
Synonym name	dead ringer-like 1 (Drosophila)
	ortholog of mouse B cell regulator of 2gH transcription (BRIGHT)
	B-cell regulator of IgH transcription
	E2F-binding protein 1
Synonym symbol(s)	BRIGHT, DRX, DRI1, E2FBP1, DRIL1, DRIL3

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	component of a cluster of paralogous genes on chromosomes 15 and 19
STRUCTURE	46.78 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - ARID3A - D19S886 /PJS1 - qter
Authors	Kortschak (98)

regionally located

tightly linked to D19S886

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005224 9 - 2823 - 593 - 2002 11812999

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Nervous brain diencephalon thalamus   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone subchondral     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens

cell lineage	in B lymphocyte lineage cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a functional nuclear localization signal to the N-terminal region of REKLES, a domain conserved within ARID3 paralogues
	one DNA binding protein containing one AT/rich interaction domain (ARID)
	one nucleosome assembly protein (NAP) domain
	AAs within the C terminal REKLES domain containing its nuclear export signal, whose regulation is primarily responsible for its shuttling

HOMOLOGY

interspecies	homolog to murine Bright (B cell regulator of IgH transcription)
	homolog to Drosophila dead ringer

intraspecies

paralog to DRIL2

Homologene

FAMILY

ARID (AT-rich interaction domain) family

CATEGORY

immunity/defense , regulatory , DNA associated , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
text	actively shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner

basic FUNCTION	playing a role in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification
	regulation of its cellular localization appears to be required for its function
	nuclear matrix-associated transcription factor that stimulates immunoglobulin heavy chain (IgH) expression and Cyclin E1/E2F-dependent cell cycle progression
	contributor to accessibility of the IgH enhancer
	B cell-specific, matrix association (or attachment) region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent cell cycle progression
	A+T-rich interaction domain protein, originally discovered in B lymphocyte lineage cells
	activator of immunoglobulin heavy-chain transcription and proto-oncogene
	transcriptional regulator required to program both hematopoietic stem cell and lineage-specific differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to promoter proximal site

RNA

small molecule

protein	binding partner for ID1 (shares structural similarities with ID1 and recently implicated in TGF-beta1 signaling during embryogenesis
	B-cell-restricted factor that complexes with Bruton tyrosine kinase (BTK) and its substrate, transcription initiation factor-I (GTF2I), to activate immunoglobulin heavy chain gene transcription in the nucleus
	transiently interacts with sumoylation enzymes, blocks calcium flux and phosphorylation of BTK and GTF2II and is then discharged from lipid rafts as a Sumo-I-modified form
	bound to its binding sites in the CDKN1A promoter
	LIN28B promotes fetal B lymphopoiesis through the transcription factor ARID3A
	ARID3A is important for IFNA1 expression and show a strong association between ARID3A expression and transcription of genes associated with lupus IFN signatures

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in lungs from patients with idiopathic pulmonary fibrosis and was regulated by TGF-beta1 in human fibroblasts

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

hematopoietic potential of Bright(-/-) mice is markedly reduced