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FLASH GENE
Symbol ARID3A contributors: mct - updated : 03-09-2014
HGNC name AT rich interactive domain 3A (BRIGHT-like)
HGNC id 3031
Location 19p13.3      Physical location : 926.036 - 972.791
Synonym name
  • dead ringer-like 1 (Drosophila)
  • ortholog of mouse B cell regulator of 2gH transcription (BRIGHT)
  • B-cell regulator of IgH transcription
  • E2F-binding protein 1
  • Synonym symbol(s) BRIGHT, DRX, DRI1, E2FBP1, DRIL1, DRIL3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of paralogous genes on chromosomes 15 and 19
    STRUCTURE 46.78 kb     9 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - ARID3A - D19S886 /PJS1 - qter
    Authors Kortschak (98)
    regionally located tightly linked to D19S886
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2823 - 593 - 2002 11812999
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Nervousbraindiencephalonthalamus highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage in B lymphocyte lineage cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a functional nuclear localization signal to the N-terminal region of REKLES, a domain conserved within ARID3 paralogues
  • one DNA binding protein containing one AT/rich interaction domain (ARID)
  • one nucleosome assembly protein (NAP) domain
  • AAs within the C terminal REKLES domain containing its nuclear export signal, whose regulation is primarily responsible for its shuttling
  • HOMOLOGY
    interspecies homolog to murine Bright (B cell regulator of IgH transcription)
    homolog to Drosophila dead ringer
    intraspecies paralog to DRIL2
    Homologene
    FAMILY ARID (AT-rich interaction domain) family
    CATEGORY immunity/defense , regulatory , DNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • actively shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner
  • basic FUNCTION
  • playing a role in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification
  • regulation of its cellular localization appears to be required for its function
  • nuclear matrix-associated transcription factor that stimulates immunoglobulin heavy chain (IgH) expression and Cyclin E1/E2F-dependent cell cycle progression
  • contributor to accessibility of the IgH enhancer
  • B cell-specific, matrix association (or attachment) region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent cell cycle progression
  • A+T-rich interaction domain protein, originally discovered in B lymphocyte lineage cells
  • activator of immunoglobulin heavy-chain transcription and proto-oncogene
  • transcriptional regulator required to program both hematopoietic stem cell and lineage-specific differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to promoter proximal site
    RNA
    small molecule
    protein
  • binding partner for ID1 (shares structural similarities with ID1 and recently implicated in TGF-beta1 signaling during embryogenesis
  • B-cell-restricted factor that complexes with Bruton tyrosine kinase (BTK) and its substrate, transcription initiation factor-I (GTF2I), to activate immunoglobulin heavy chain gene transcription in the nucleus
  • transiently interacts with sumoylation enzymes, blocks calcium flux and phosphorylation of BTK and GTF2II and is then discharged from lipid rafts as a Sumo-I-modified form
  • bound to its binding sites in the CDKN1A promoter
  • LIN28B promotes fetal B lymphopoiesis through the transcription factor ARID3A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in lungs from patients with idiopathic pulmonary fibrosis and was regulated by TGF-beta1 in human fibroblasts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    hematopoietic potential of Bright(-/-) mice is markedly reduced