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FLASH GENE
Symbol API5 contributors: mct/npt - updated : 10/09/2008
HGNC name apoptosis inhibitor 5
HGNC id 594
Location 11p11.2      Physical location : 43.333.504 - 43.366.080
Synonym name
  • FGF2-interacting-factor
  • API5-like 1
  • fibroblast growth factor 2-interacting factor 2
  • migration-inducing protein MIG8
  • antiapoptosis clone 11 protein
    • Synonym symbol(s) AAC11, FIF, API5L1
    DNA
    TYPE functioning gene
    STRUCTURE 32.54 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3752 55 504 - Tewari (1997), Morris (2006)
    containing a leucine zipper domain
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a leucine-zipper domain that dictates, upon oligomerization, its interaction with ACIN1 as well as the antiapoptotic effect of ACIN1 on drug-induced cell death
  • three overlapping hydrophobic heptad repeats
    • HOMOLOGY
    Homologene
    FAMILY
  • API5 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting downstream of E2F and suppressing E2F-dependent apoptosis without generally blocking E2F-dependent transcription
  • survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to ACIN1 and prevents ACIN1-mediated DNA fragmentation
    • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein FGF2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate metastasis-related and apoptosis-inhibiting gene in cervical cancer
    Marker
    Therapy target inhibition of Api5 function might offer a possible mechanism for antitumor exploitation
    SystemTypeDisorderPubmed
    cancer  
    targeting AAC-11 might be a potent strategy for cancer treatment by sensitization of tumour cells to chemotherapeutic drugs
    cancer  
    inhibition of Api5 function might offer a possible mechanism for antitumor exploitation
    ANIMAL & CELL MODELS