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FLASH GENE
Symbol API5 contributors: mct/npt - updated : 10/09/2008
HGNC name apoptosis inhibitor 5
HGNC id 594
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousbrain   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a leucine-zipper domain that dictates, upon oligomerization, its interaction with ACIN1 as well as the antiapoptotic effect of ACIN1 on drug-induced cell death
  • three overlapping hydrophobic heptad repeats
  • HOMOLOGY
    Homologene
    FAMILY
  • API5 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting downstream of E2F and suppressing E2F-dependent apoptosis without generally blocking E2F-dependent transcription
  • survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to ACIN1 and prevents ACIN1-mediated DNA fragmentation
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein FGF2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate metastasis-related and apoptosis-inhibiting gene in cervical cancer
    Marker
    Therapy target inhibition of Api5 function might offer a possible mechanism for antitumor exploitation
    SystemTypeDisorderPubmed
    cancer  
    targeting AAC-11 might be a potent strategy for cancer treatment by sensitization of tumour cells to chemotherapeutic drugs
    cancer  
    inhibition of Api5 function might offer a possible mechanism for antitumor exploitation
    ANIMAL & CELL MODELS