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FLASH GENE
Symbol AP2A1 contributors: - updated : 01-06-2006
HGNC name adaptor-related protein complex 2, alpha 1 subunit
HGNC id 561
Location 19q13.3      Physical location : 50.270.179 - 50.310.367
Synonym name
  • 100 kDa coated vesicle protein A
  • adaptin alpha
  • plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
  • clathrin-associated/assembly/adaptor protein, large, alpha 1
  • AP-2 complex subunit alpha-1
    • Synonym symbol(s) ADTAA, CLAPA1, AP2-ALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - MAP1A - FUT1 - HRC - BCAT2 - SNRP70 - RPS11 - CD37 - AP2A1 - FLT3LG - D19S907 - POLD1 - KLK3 - ETFB ETFB - KLK1 - CD33 - FPR1 - FPRL1 - D19S571 - D19S927 - D19S418 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3499 107.6 977 forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon Scorilas
    - splicing 3433 105.1 955 widely expressed in tissues and also in breast cancer and in prostate carcinoma cells Scorilas
    lacking an internal exon
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland    
    Nervousbrain    
     brainhindbraincerebellum  
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text forebrain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ap2a1 (98.5pc)
    Homologene
    FAMILY adaptor complexes large subunits family
    CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text endocytic coated vesicles
    basic FUNCTION AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component subunit of AP-2 adaptor complex, clathrin coat assembly complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein HIP1
    cell & other
    REGULATION
    activated by the autonomous E1A,requiring derepression of AP2A promoter by interaction of E1A with KLF12 corepressor CTBP1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS