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FLASH GENE
Symbol AP2A1 contributors: - updated : 01-06-2006
HGNC name adaptor-related protein complex 2, alpha 1 subunit
HGNC id 561
Location 19q13.3      Physical location : 50.270.179 - 50.310.367
Synonym name
  • 100 kDa coated vesicle protein A
  • adaptin alpha
  • plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
  • clathrin-associated/assembly/adaptor protein, large, alpha 1
  • AP-2 complex subunit alpha-1
    • Synonym symbol(s) ADTAA, CLAPA1, AP2-ALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - MAP1A - FUT1 - HRC - BCAT2 - SNRP70 - RPS11 - CD37 - AP2A1 - FLT3LG - D19S907 - POLD1 - KLK3 - ETFB ETFB - KLK1 - CD33 - FPR1 - FPRL1 - D19S571 - D19S927 - D19S418 - qter
    Authors Gene Map (98)
    Physical map
    CD37 19q13.3 CD37 antigen DKKL1-pending 19q13.33 soggy-1 gene TEAD2 19q13.3 TEA domain family member 2 FLJ32658 19q13.33 hypothetical protein FLJ32658 TIP39 19q13.33 tuberoinfundibular 39 residue protein precursor LOC390955 19 similar to ENSANGP00000004655 SLC17A7 19q13 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 FLJ20643 19q13.33 hypothetical protein FLJ20643 MGC10204 19q13.33 hypothetical protein MGC10204 FLT3LG 19q13.3 fms-related tyrosine kinase 3 ligand RPL13A 19q13.4 ribosomal protein L13a RPS11 19q13.3 ribosomal protein S11 FCGRT 19q13.3 Fc fragment of IgG, receptor, transporter, alpha RCN3 19q13.33 reticulocalbin 3, EF-hand calcium binding domain NOSIP 19q13.3 nitric oxide synthase interacting protein PRRG2 19q13.33 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 KIAA1205 19q13.33 KIAA1205 RRAS 19q13.3-q13.4 related RAS viral (r-ras) oncogene homolog SR-A1 19q13.3-q13.4 serine arginine-rich pre-mRNA splicing factor SR-A1 IRF3 19q13.3 interferon regulatory factor 3 BCL2L12 19q13.3 BCL2-like 12 (proline rich) HRMT1L2 19q13-3 HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae) LOC199800 19q13.33 hypothetical protein LOC199800 CPT1C 19q13.33 hypothetical protein LOC199800 LOC388556 19 hypothetical gene supported by NM_001013 TSKS 19q13.3 hypothetical gene supported by NM_001013 AP2A1 19q13.3 adaptor-related protein complex 2, alpha 1 subunit FLJ22688 19q13.33 hypothetical protein FLJ22688 TCBAP0758 19q13.3 hypothetical protein TCBAP0758 PTOV1 19q13.33 prostate tumor over expressed gene 1 PNKP 19q13.3-q13.4 polynucleotide kinase 3'-phosphatase MGC2865 19q13.33 hypothetical protein MGC2865 FLJ12168 IL4I1 19q13.3-q13.4 interleukin 4 induced 1 NUP62 19q13.33 nucleoporin 62kDa ATF5 19q13.3 activating transcription factor 5 SIGLEC11 19q13.33 sialic acid binding Ig-like lectin 11 VRK3 19q13 vaccinia related kinase 3 ZNF473 19q13.33 zinc finger protein 473 LOC342917 19q13.33 similar to kruppel-related zinc finger protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3499 107.6 977 forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon Scorilas
    - splicing 3433 105.1 955 widely expressed in tissues and also in breast cancer and in prostate carcinoma cells Scorilas
    lacking an internal exon
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland    
    Nervousbrain    
     brainhindbraincerebellum  
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text forebrain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ap2a1 (98.5pc)
    Homologene
    FAMILY adaptor complexes large subunits family
    CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text endocytic coated vesicles
    basic FUNCTION AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component subunit of AP-2 adaptor complex, clathrin coat assembly complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein HIP1
    cell & other
    REGULATION
    activated by the autonomous E1A,requiring derepression of AP2A promoter by interaction of E1A with KLF12 corepressor CTBP1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS