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FLASH GENE
Symbol AP2A1 contributors: - updated : 01-06-2006
HGNC name adaptor-related protein complex 2, alpha 1 subunit
HGNC id 561
DNA
TYPE functioning gene
STRUCTURE 40.00 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - MAP1A - FUT1 - HRC - BCAT2 - SNRP70 - RPS11 - CD37 - AP2A1 - FLT3LG - D19S907 - POLD1 - KLK3 - ETFB ETFB - KLK1 - CD33 - FPR1 - FPRL1 - D19S571 - D19S927 - D19S418 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3499 107.6 977 forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon Scorilas
- splicing 3433 105.1 955 widely expressed in tissues and also in breast cancer and in prostate carcinoma cells Scorilas
lacking an internal exon
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland    
Nervousbrain    
 brainhindbraincerebellum  
 spinal cord    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandular  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text forebrain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Ap2a1 (98.5pc)
Homologene
FAMILY adaptor complexes large subunits family
CATEGORY adaptor , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,vesicle
text endocytic coated vesicles
basic FUNCTION AP2 adaptor complex linking clathrin to receptors in coated vesicles, clathrin-associated protein complexes are believed to interact with cytoplasmic domains of transmembrane proteins leading to their selection and concentration
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
PATHWAY
metabolism
signaling
a component subunit of AP-2 adaptor complex, clathrin coat assembly complex
INTERACTION
DNA
RNA
small molecule
protein HIP1
cell & other
REGULATION
activated by the autonomous E1A,requiring derepression of AP2A promoter by interaction of E1A with KLF12 corepressor CTBP1
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS