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FLASH GENE
Symbol AOAH contributors: npt/ - updated : 23-05-2005
HGNC name acyloxyacyl hydrolase (neutrophil)
HGNC id 548
Location 7p14-p12      Physical location : 36.552.548 - 36.764.154
Synonym name acyloxyacyl hydrolase
EC.number 3.1.1.77
DNA
TYPE functioning gene
STRUCTURE 211.42 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389479 7 similar to hypothetical protein FLJ32949 MTPN 7q33-q35 myotrophin TBX20 7p15-p14 T-box 20 FLJ22313 7p14.2 hypothetical protein FLJ22313 CDC10 7p14.3-p14.1 CDC10 cell division cycle 10 homolog (S. cerevisiae) LOC392884 7 similar to cell division cycle 10 homolog FLJ22313 7p14.2 hypothetical protein FLJ22313 KIAA1706 7p14 KIAA1706 protein CDC10 7p14.3-p14.1 CDC10 cell division cycle 10 homolog (S. cerevisiae) LOC392014 7 similar to cell division cycle 10 homolog KIAA0895 7p14.1 KIAA0895 protein LOC392996 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 ANLN 7p15-p14 anillin, actin binding protein (scraps homolog, Drosophila) KIAA1706 7p14 KIAA1706 protein AOAH 7p14-p12 acyloxyacyl hydrolase (neutrophil) LOC392795 7 LOC392795 CHRM2 7q31-q35 cholinergic receptor, muscarinic 2 KIAA0895 7p14.1 KIAA0895 protein LOC392796 7 LOC392796 ANLN 7p15-p14 anillin, actin binding protein (scraps homolog, Drosophila) LOC392885 7 similar to nucleophosmin/B23.2 ELMO1 7p14.3-p14.1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) PTN 7q33-q34 pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) AOAH 7p14-p12 acyloxyacyl hydrolase (neutrophil) DGKI 7q32.3-q33 diacylglycerol kinase, iota NPM1P18 7p14.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 18 ELMO1 7p14.3-p14.1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) CREB3L2 7q33-q34 cAMP responsive element binding protein 3-like 2 LOC392886 7 similar to DKFZP566B183 protein AKR1D1 7q32-q33 aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) GPR141 7p14.1 G protein-coupled receptor 141 TXNDC3 7p15.2 thioredoxin domain containing 3 (spermatozoa) SFRP4 7p14.1 secreted frizzled-related protein 4 UCC1 7p14.1 secreted frizzled-related protein 4 LOC392997 7 similar to dJ753D5.2 (novel protein similar to RPS17 (40S ribosomal protein S17)) LOC340285 7p14.1 similar to DKFZP566B183 protein LOC392998 7 similar to prothymosin, alpha (gene sequence 28)
RNA
TRANSCRIPTS type messenger
text precursor of two disulfide-linked subunits
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2474 65.1 575 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrinethyroid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lipase consensus sequence in large subunit saposin homology region in small subunit
  • mono polymer heteromer , dimer
    isoforms Precursor precursor of two disulfide-linked subunits
    HOMOLOGY
    interspecies homolog to murine Aoah
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • specifically hydrolyzing the secondary acyl chains of the liposaccharide found in the walls of gram-negative bacteria
  • two-subunit lipase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS