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FLASH GENE
Symbol ANXA8 contributors: mct - updated : 30-03-2016
HGNC name annexin A8
HGNC id 546
Location 10q11.22      Physical location : 47.157.985 - 48.271.366
Synonym name vascular anticoagulant-beta
Synonym symbol(s) ANX8, FLJ53095, VAC-beta
DNA
TYPE functioning gene
STRUCTURE 525.78 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC340765 10q11.21 similar to double homeobox, 4; double homeobox protein 4 LOC387663 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC389957 10 similar to breast cancer antigen NY-BR-1.1 LOC389958 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC220974 10q11.21 similar to olfactory receptor GA_x54KRFPKN04-58149882-58150865 OR13A1 10q22.2 olfactory receptor, family 13, subfamily A, member 1 ALOX5 10q11.2 arachidonate 5-lipoxygenase MIR 10q11.22 c-mir, cellular modulator of immune recognition LOC387664 10 LOC387664 ANUBL1 10q11.22 AN1, ubiquitin-like, homolog (Xenopus laevis) LOC143158 10q11.22 similar to ARF GTPase-activating protein LOC389959 10 similar to KIAA0592 protein KIAA0592 10q11.1 KIAA0592 protein MRIP2 10q11.22 ARF GTPase-activating protein LOC389960 10 hypothetical gene supported by AY258587; NM_003631 LOC387665 10 similar to ARF GTPase-activating protein LOC387666 10 similar to Ribosome biogenesis protein BMS1 homolog LOC389961 10 hypothetical gene supported by L25628 RHEBP1 10q11 Ras-homolog enriched in brain pseudogene 1 SYT15 10q11.1 synaptotagmin XV PPYR1 10q11.2-q21.2 pancreatic polypeptide receptor 1 LOC387667 10 hypothetical gene supported by BC004945; NM_002136 LOC220466 10q11.22 similar to ARF GTPase-activating protein LOC340733 10q11.22 similar to Dual specificity phosphatase 8 CTSLL2 10q22 cathepsin L-like 2 LOC340844 10q11.22 similar to Ahcy protein LOC195977 10q11.22 hypothetical protein LOC195977 LOC387668 10 similar to ARF GTPase-activating protein ANXA8 10q11.2 annexin A8 FLJ10824 10q11.22 hypothetical protein FLJ10824 LOC389963 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC387669 10 LOC387669 LOC387670 10 hypothetical gene supported by NM_133446 ZNF488 10q11.22 zinc finger protein 488 RBP3 10q11.2 retinol binding protein 3, interstitial GDF2 10q11.22 growth differentiation factor 2 GDF10 10q21.1 growth differentiation factor 10 DKFZP566K0524 10q11.22 DKFZP566K0524 protein LOC387671 10 similar to ARF GTPase-activating protein LOC387672 10 similar to Ribosome biogenesis protein BMS1 homolog LOC387673 10 similar to Glutamate dehydrogenase, mitochondrial precursor (GDH) LOC338598 10q11.22 similar to hypothetical protein MGC5560 LOC118706 10q11.22 similar to ARF GTPase-activating protein LOC387674 10 similar to Ribosome biogenesis protein BMS1 homolog MGC35285 10q11.22 hypothetical protein MGC35285 MAPK8 10q11.2 mitogen-activated protein kinase 8 RhoGAP2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2070 36.7 327 - 2014 24769558
10 - 1905 - 265 - 2014 24769558
12 - 2205 - 365 - 2014 24769558
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Respiratorylung    
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly Homo sapiens
Epithelialbarrier/liningendothelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
Skeletonosteoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa8
    Homologene
    FAMILY
  • calcium dependent phospholipid binding protein family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • vascular anticoagulation, indirect inhibitor of the thromboplastin specific complex involved in blood coagulation cascade
  • regulates late endosome organization and function
  • is a gene strongly induced late in osteoclast differentiation and a protein that regulates formation of the cell characteristic actin ring
  • might play an important role in calcium fluctuation-mediated HIF1A transcriptional activation and cell viability
  • controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • phospholipid
  • protein
  • ANXA2, ANXA8, and ANXA9 interacted with proAREG and ADAM17 on the cell surface
  • ANXA2, ANXA8, ANXA9, play an essential role in the ADAM17-mediated ectodomain shedding of EGFR ligands
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --other  
    ectopically expressed in pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • both KRT19 and ANXA8 mRNA may be useful markers for detecting lymph node metastases in OSCC (oral squamous cell carcinoma) patients
  • Therapy target
    ANIMAL & CELL MODELS
  • Anxa8 expression in the mouse mammary gland was strong during pre-puberty before the expansion of the rudimentary ductal network and was limited to a distinct subpopulation of ductal luminal epithelial cells