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FLASH GENE

Symbol

ANXA8

contributors: mct - updated : 30-03-2016

HGNC name	annexin A8
HGNC id	546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001040084 12 - 2070 NP_001035173 36.7 327 - 2014 24769558 NM_001271703 10 - 1905 NP_001258632 - 265 - 2014 24769558 NM_001271702 12 - 2205 NP_001258631 - 365 - 2014 24769558

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Respiratory lung         Skin/Tegument skin         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Homo sapiens Epithelial barrier/lining endothelium

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Skeleton osteoblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a relatively short N terminus
	a C terminal "core" region made of four repeats homolog to the endonexin fold

HOMOLOGY

interspecies

homolog to murine Anxa8

Homologene

FAMILY

calcium dependent phospholipid binding protein family

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic

basic FUNCTION	vascular anticoagulation, indirect inhibitor of the thromboplastin specific complex involved in blood coagulation cascade
	regulates late endosome organization and function
	is a gene strongly induced late in osteoclast differentiation and a protein that regulates formation of the cell characteristic actin ring
	might play an important role in calcium fluctuation-mediated HIF1A transcriptional activation and cell viability
	controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, other,
	Ca2+
	phospholipid

protein	ANXA2, ANXA8, and ANXA9 interacted with proAREG and ADAM17 on the cell surface
	ANXA2, ANXA8, ANXA9, play an essential role in the ADAM17-mediated ectodomain shedding of EGFR ligands

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tumoral     --other   ectopically expressed in pancreatic cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	both KRT19 and ANXA8 mRNA may be useful markers for detecting lymph node metastases in OSCC (oral squamous cell carcinoma) patients
Therapy target

ANIMAL & CELL MODELS

Anxa8 expression in the mouse mammary gland was strong during pre-puberty before the expansion of the rudimentary ductal network and was limited to a distinct subpopulation of ductal luminal epithelial cells