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FLASH GENE

Symbol

ANKRD26

contributors: mct - updated : 05-02-2011

HGNC name	ankyrin repeat domain 26
HGNC id	29186

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	THC2 thrombocytopenia 2
Location	10p12.1      Physical location : 27.293.044 - 27.389.427
Synonym name	ankyrin repeat domain-containing protein 26
	KIAA1074 protein
Synonym symbol(s)	KIAA1074, MGC163325, bA145E8.1, FLJ14813

DNA

TYPE	functioning gene
STRUCTURE	96.38 kb     34 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014915 34 - 6816 NP_055730 196.3 1710 - 2003 12890928

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       lowly   thymus       lowly Nervous brain diencephalon hypothalamus nucleus accumbens highly Homo sapiens Reproductive female system breast mammary gland       male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	placenta, liver, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four N-terminal ankyrin repeats
	a C-terminal coiled-coil region

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
	has the genomic structure of the possible ancestor of ANKRD30A and all POTE family genes
	protein associated with the inner aspect of the cell membrane and that contain both ankyrin repeats and spectrin helices, motifs known to interact with signaling proteins in the cell
	ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

THC2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

homozygous mutant Ankrd26 mice develop extreme obesity, insulin resistance, and an increase in body size