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FLASH GENE
Symbol ANKRD26 contributors: mct - updated : 05-02-2011
HGNC name ankyrin repeat domain 26
HGNC id 29186
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   lowly
 thymus   lowly
Nervousbraindiencephalonhypothalamusnucleus accumbenshighly Homo sapiens
Reproductivefemale systembreastmammary gland  
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text placenta, liver, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N-terminal ankyrin repeats
  • a C-terminal coiled-coil region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
  • has the genomic structure of the possible ancestor of ANKRD30A and all POTE family genes
  • protein associated with the inner aspect of the cell membrane and that contain both ankyrin repeats and spectrin helices, motifs known to interact with signaling proteins in the cell
  • ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THC2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    homozygous mutant Ankrd26 mice develop extreme obesity, insulin resistance, and an increase in body size