| 1 | AKT1, CASTOR1, MTOR, RNF167
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| RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
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| Li T, Wang X, Ju E, da Silva SR, Chen L, Zhang X, Wei S, Gao SJ.
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| Nat Commun. Feb 16;12(1):1055. doi: 10.1038/s41467-021-21206-3. 2021
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| 2 | AKT1, FSCN1, HBEGF, SOX2
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| SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF
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| Xiao W, Zheng S, Xie X, Li X, Zhang L, Yang A, Wang J, Tang H, Xie X.
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| Mol Ther Oncolytics. Mar 13;17:118-129. doi: 10.1016/j.omto.2020.03.001. 2020
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| 3 | AKT1, MASTL
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| AKT Regulates Mitotic Progression of Mammalian Cells by Phosphorylating MASTL, Leading to Protein Phosphatase 2A Inactivation.
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| Reshi I, Nisa MU, Farooq U, Gillani SQ, Bhat SA, Sarwar Z, Nabi N, Fazili KM, Andrabi S.
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| Mol Cell Biol. Apr 28;40(10):e00366-18. doi: 10.1128/MCB.00366-18. 2020
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| 4 | AKT1, TIGAR
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| TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma.
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| Tang Z, He Z.
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| Oncol Lett 18(3):2509-2517. doi: 10.3892/ol.2019.10574. Epub 2019 Jul 5.
2019
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| 5 | AKT1, CDH1, DSC3
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| Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.
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| Cui T, Yang L, Ma Y, Petersen I, Chen Y.
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| Exp Cell Res 378(2):124-130. doi: 10.1016/j.yexcr.2019.03.015. Epub 2019 Mar 8.
2019
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| 6 | AKT1, SAV1
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| MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
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| Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, Kim WY, Earp HS, Liu P.
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| Nat Commun. Apr 3;10(1):1515. doi: 10.1038/s41467-019-09233-7. 2019
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| 7 | AKT1, HDAC3, PDCD5
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| Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
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| Lee SH, Seo J, Park SY, Jeong MH, Choi HK, Lee CJ, Kim MJ, Guk G, Lee S, Park H, Jeong JW, Ha CH, Park S, Yoon HG.
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| Proc Natl Acad Sci U S A 115(18):4672-4677. doi: 10.1073/pnas.1712918115. Epub 2018 Mar 27.
2018
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| 8 | AKT1, EPS8L3, FOXO1
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| Overexpression of EPS8L3 promotes cell proliferation by inhibiting the transactivity of FOXO1 in HCC.
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| Zeng CX, Tang LY, Xie CY, Li FX, Zhao JY, Jiang N, Tong Z, Fu SB, Wen FJ, Feng WS.
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| Neoplasma 65(5):701-707. doi: 10.4149/neo_2018_170725N503. Epub 2018 Jun 17.
2018
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| 9 | AKT1, AKT2, VRK2
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| Functional characterization of lysosomal interaction of Akt with VRK2.
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| Hirata N, Suizu F, Matsuda-Lennikov M, Tanaka T, Edamura T, Ishigaki S, Donia T, Lithanatudom P, Obuse C, Iwanaga T, Noguchi M.
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| Oncogene Oct;37(40):5367-5386. doi: 10.1038/s41388-018-0330-0. Epub 2018 Jun 5. 2018
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| 10 | AIPL1, AKT1, DIAPH2, ZP3
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| ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis.
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| Gao LL, Zhou CX, Zhang XL, Liu P, Jin Z, Zhu GY, Ma Y, Li J, Yang ZX, Zhang D.
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| Sci Rep 7:41272. doi: 10.1038/srep41272.
2017
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| 11 | AKT1, TRIM14
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| TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
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| Xu G, Guo Y, Xu D, Wang Y, Shen Y, Wang F, Lv Y, Song F, Jiang D, Zhang Y, Lou Y, Meng Y, Yang Y, Kang Y.
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| Sci Rep 7:42411. doi: 10.1038/srep42411.
2017
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| 12 | AKT1, ERBB2
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| The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.
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| Mathavan K, Khedgikar V, Bartolo V, Alfandari D.
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| PLoS One 12(11):e0188963. doi: 10.1371/journal.pone.0188963. eCollection 2017.
2017
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| 13 | AKT1, FOXO3, MUL1
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| FOXO3 induces ubiquitylation of AKT through MUL1 regulation.
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| Kim SY, Kim HJ, Byeon HK, Kim DH, Kim CH.
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| Oncotarget 8(66):110474-110489. doi: 10.18632/oncotarget.22793. eCollection 2017 Dec 15.
2017
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| 14 | AKT1, BCL3, MAPK1
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| Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
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| Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G.
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| Mol Cell. Aug 3;67(3):484-497.e5. doi: 10.1016/j.molcel.2017.06.011. Epub 2017 Jul 6. 2017
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| 15 | AKT1, MAPK14, TNFAIP8L2
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| TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways.
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| Zhang Z, Liu L, Liu C, Cao S, Zhu Y, Mei Q.
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| Oncol Rep 36(6):3311-3316. doi: 10.3892/or.2016.5192.
2016
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| 16 | AKT1, SMYD3
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| SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
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| Yoshioka Y, Suzuki T, Matsuo Y, Nakakido M, Tsurita G, Simone C, Watanabe T, Dohmae N, Nakamura Y, Hamamoto R.
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| Oncotarget 7(46):75023-75037. doi: 10.18632/oncotarget.11898.
2016
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| 17 | AKT1, FKBP5
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| A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies.
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| Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L.
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| Psychoneuroendocrinology 52:43-58. doi: 10.1016/j.psyneuen.2014.11.005. Epub 2014 Nov 11.
2015
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| 18 | AKT1, SGK1
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| Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.
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| Satoh N, Nakamura M, Suzuki M, Suzuki A, Seki G, Horita S.
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| Biomed Res Int 2015:971697. doi: 10.1155/2015/971697. Epub 2015 Sep 28. Review.
2015
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| 19 | AKT1, CCDC88A
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| Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
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| Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, Ichihara S, Furukawa K, Maeda K, Murohara T, Takahashi M.
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| Cancer Res 75(5):813-23. doi: 10.1158/0008-5472.CAN-14-1317.
2015
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| 20 | AKT1, MAPK14, NFKBIA, TNFAIP8L2
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| TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression.
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| Liu QQ, Zhang FF, Wang F, Qiu JH, Luo CH, Zhu GY, Liu YF.
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| PLoS One 10(5):e0126176. doi: 10.1371/journal.pone.0126176.
2015
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| 21 | AKT1, PDE3B
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| The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin.
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| DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ.
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| Mol Cell Biol 35(16):2752-60. doi: 10.1128/MCB.00422-15. Epub 2015 Jun 1. 2015
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| 22 | AKT1, GSK3B, ZNRF1
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| Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
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| Wakatsuki S, Furuno A, Ohshima M, Araki T.
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| J Cell Biol 211(4):881-96. doi: 10.1083/jcb.201506102. Epub 2015 Nov 16.
2015
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| 23 | AKT1, IFNA1, IL2, IL7
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| Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
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| Nguyen TP, Bazdar DA, Mudd JC, Lederman MM, Harding CV, Hardy GA, Sieg SF.
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| J Leukoc Biol 97(6):1139-46. doi: 10.1189/jlb.4A0714-345RR. Epub 2015 Mar 17.
2015
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| 24 | AKT1, BCL2L12, CD82, STAT5A
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| The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells.
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| Nishioka C, Ikezoe T, Takeuchi A, Nobumoto A, Tsuda M, Yokoyama A.
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| Leukemia 29(12):2296-306. doi: 10.1038/leu.2015.219. Epub 2015 Aug 11.
2015
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| 25 | AKT1
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| Significance of Akt activation and AKT gene increases in soft tissue tumors.
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| Dobashi Y, Sato E, Oda Y, Inazawa J, Ooi A.
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| Hum Pathol 45(1):127-36. doi: 10.1016/j.humpath.2013.06.024.
2014
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| 26 | AKT1, CARD11
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| Phosphorylation of Carma1, but not Bcl10, by Akt regulates TCR/CD28-mediated NF-κB induction and cytokine production.
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| Cheng J, Hamilton KS, Kane LP.
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| Mol Immunol 59(1):110-6. doi: 10.1016/j.molimm.2014.01.011. Epub 2014 Feb 16.
2014
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| 27 | AKT1, FAM3A, PIK3CA
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| FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis.
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| Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J, Guan Y.
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| Hepatology 59(5):1779-90. doi: 10.1002/hep.26945. Epub 2014 Mar 27.
2014
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| 28 | AKT1, AKT2
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| Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
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| Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.
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| Am J Physiol Renal Physiol 307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24.
2014
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| 29 | AKT1, AKT2, AKT3
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| Differential effects of Akt isoforms on somatic cell reprogramming.
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| Tang Y, Jiang Z, Luo Y, Zhao X, Wang L, Norris C, Tian XC.
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| J Cell Sci 127(Pt 18):3998-4008. doi: 10.1242/jcs.150029. Epub 2014 Jul 18.
2014
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| 30 | AKT1, AKT2, CK2
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| Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.
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| Girardi C, James P, Zanin S, Pinna LA, Ruzzene M.
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| Biochim Biophys Acta 1843(9):1865-74. doi: 10.1016/j.bbamcr.2014.04.020. Epub 2014 Apr 24.
2014
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| 31 | AKT1, AKT2, CSNK2A1
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| Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.
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| Girardi C, James P, Zanin S, Pinna LA, Ruzzene M.
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| Biochim Biophys Acta 1843(9):1865-74. doi: 10.1016/j.bbamcr.2014.04.020. Epub 2014 Apr 24.
2014
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| 32 | AKT1, AKT2, DAB2
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| Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
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| Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.
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| Am J Physiol Renal Physiol 307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24.
2014
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| 33 | AKT1, MC1R, POMC
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| Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling.
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| Cheng LB, Cheng L, Bi HE, Zhang ZQ, Yao J, Zhou XZ, Jiang Q.
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| Biochem Biophys Res Commun 443(2):447-52. doi: 10.1016/j.bbrc.2013.11.113. Epub 2013 Dec 6.
2014
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| 34 | AKT1, TKT
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| Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis.
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| Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR.
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| Mol Cell 55(2):264-76. doi: 10.1016/j.molcel.2014.05.028. Epub 2014 Jun 26.
2014
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| 35 | AKT1, ALCAM, FOXO1
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| CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition of FOXO proteins through AKT.
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| Yu W, Wang J, Ma L, Tang X, Qiao Y, Pan Q, Yu Y, Sun F.
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| Oncol Rep 32(2):677-83. doi: 10.3892/or.2014.3226. Epub 2014 May 30.
2014
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| 36 | AKT1, PIK3CA
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| Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes.
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| Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C.
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| Am J Hum Genet 92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13.
2013
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| 37 | AKT1, LMNA
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| The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression.
|
| Bertacchini J, Beretti F, Cenni V, Guida M, Gibellini F, Mediani L, Marin O, Maraldi NM, de Pol A, Lattanzi G, Cocco L, Marmiroli S.
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| FASEB J ASEB J. 2013 Feb 21. [Epub ahead of print]
2013
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| 38 | AKT1, SMO
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| Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
|
| Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R.
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| Nat Genet 45(3):285-9. doi: 10.1038/ng.2526. Epub 2013 Jan 20.
2013
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| 39 | AKT1, PHF20
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| PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
|
| Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J.
|
| Cell Signal 25(1):74-84. doi: 10.1016/j.cellsig.2012.09.009. Epub 2012 Sep 11.
2013
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| 40 | AKT1, JADE1
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| Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.
|
| Zeng L, Bai M, Mittal AK, El-Jouni W, Zhou J, Cohen DM, Zhou MI, Cohen HT.
|
| Cancer Res 73(17):5371-80. doi: 10.1158/0008-5472.CAN-12-4707. Epub 2013 Jul 1.
2013
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| 41 | AKT1, ARHGEF3, CRTC2
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| XPLN is an endogenous inhibitor of mTORC2.
|
| Khanna N, Fang Y, Yoon MS, Chen J.
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| Proc Natl Acad Sci U S A 110(40):15979-84. doi: 10.1073/pnas.1310434110. Epub 2013 Sep 16.
2013
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| 42 | AKT1, AKT2, PDPK1
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| PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
|
| Tsuchiya A, Kanno T, Nishizaki T.
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| J Endocrinol 220(1):49-59. doi: 10.1530/JOE-13-0172. Print 2014 Jan.
2013
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| 43 | AKT1
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| Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
|
| Abdalla M, Goc A, Segar L, Somanath PR.
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| J Biol Chem 288(46):33483-93. doi: 10.1074/jbc.M113.504290. Epub 2013 Oct 8.
2013
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| 44 | AKT1
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| Akt SUMOylation regulates cell proliferation and tumorigenesis.
|
| Li R, Wei J, Jiang C, Liu D, Deng L, Zhang K, Wang P.
|
| Cancer Res 73(18):5742-53. doi: 10.1158/0008-5472.CAN-13-0538. Epub 2013 Jul 24.
2013
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| 45 | AKT1, MTOR
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| Akt/mTOR signalling in myelination.
|
| Norrmén C, Suter U.
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| Biochem Soc Trans 41(4):944-50. doi: 10.1042/BST20130046. Review.
2013
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| 46 | AKT1, PIKFYVE
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| AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
|
| Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J.
|
| Sci Signal 6(279):ra45. doi: 10.1126/scisignal.2004015.
2013
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| 47 | AKT1
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| Akt1 as a putative regulator of Hox genes.
|
| Kong KA, Yoon H, Kim MH.
|
| Gene 513(2):287-91. doi: 10.1016/j.gene.2012.10.034. Epub 2012 Nov 12.
2013
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| 48 | AKT1
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| AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
|
| Nygaard M, Soerensen M, Flachsbart F, Mengel-From J, Tan Q, Schreiber S, Nebel A, Christensen K, Christiansen L.
|
| Eur J Hum Genet 21(5):574-7. doi: 10.1038/ejhg.2012.196. Epub 2012 Aug 29.
2013
|
| 49 | AKT1, MTOR, PIK3CA
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| The PI3K/AKT/mTOR signaling pathway is overactivated in primary aldosteronism.
|
| Su H, Gu Y, Li F, Wang Q, Huang B, Jin X, Ning G, Sun F.
|
| PLoS One 8(4):e62399. doi: 10.1371/journal.pone.0062399. Print 2013.
2013
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| 50 | ACTA2, AKT1
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| Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
|
| Abdalla M, Goc A, Segar L, Somanath PR.
|
| J Biol Chem 288(46):33483-93. doi: 10.1074/jbc.M113.504290. Epub 2013 Oct 8.
2013
|
| 51 | AKT1, CWS6
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| Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
|
| Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C.
|
| Am J Hum Genet 92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13.
2013
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| 52 | AKT1, TPP1
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| Akt regulates TPP1 homodimerization and telomere protection.
|
| Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z.
|
| Aging Cell 12(6):1091-9. doi: 10.1111/acel.12137. Epub 2013 Aug 11.
2013
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| 53 | AKT1, RIPK1
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| Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
|
| McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A.
|
| PLoS One 8(3):e56576. doi: 10.1371/journal.pone.0056576. Epub 2013 Mar 1.
2013
|
| 54 | AKT1, SDC4
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| Syndecan 4 regulation of PDK1-dependent Akt activation.
|
| Ju R, Simons M.
|
| Cell Signal 25(1):101-5. doi: 10.1016/j.cellsig.2012.09.007. Epub 2012 Sep 10.
2013
|
| 55 | AKT1, PHF20
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| Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.
|
| Park S, Kim D, Dan HC, Chen H, Testa JR, Cheng JQ.
|
| J Biol Chem 287(14):11151-63. doi: 10.1074/jbc.M111.333922. Epub 2012 Feb 14.
2012
|
| 56 | AKT1
|
| The role of Akt signalling in the mammalian ovary.
|
| Cecconi S, Mauro A, Cellini V, Patacchiola F.
|
| Int J Dev Biol 56(10-12):809-17. doi: 10.1387/ijdb.120146sc. Review.
2012
|
| 57 | AKT1, AKT2
|
| Molecular alterations in AKT and its protein activation in human lung carcinomas.
|
| Dobashi Y, Kimura M, Matsubara H, Endo S, Inazawa J, Ooi A.
|
| Hum Pathol 43(12):2229-40. doi: 10.1016/j.humpath.2012.03.015. Epub 2012 Jun 28.
2012
|
| 58 | AKT1, PROM1
|
| CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma.
|
| Kimura T, Wang L, Tabu K, Nishihara H, Mashita Y, Kikuchi N, Tanino M, Hiraga H, Tanaka S.
|
| Cancer Invest 30(5):390-7. doi: 10.3109/07357907.2012.672607.
2012
|
| 59 | AKT1, IGF2
|
| Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
|
| Kent LN, Ohboshi S, Soares MJ.
|
| Int J Dev Biol 56(4):255-61. doi: 10.1387/ijdb.113407lk.
2012
|
| 60 | AKT1, CYLD
|
| CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt.
|
| Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD.
|
| Nat Commun 3:771. doi: 10.1038/ncomms1776.
2012
|
| 61 | AKT1, AKT2
|
| Differential function of Akt1 and Akt2 in human adipocytes.
|
| Fischer-Posovszky P, Tews D, Horenburg S, Debatin KM, Wabitsch M.
|
| Mol Cell Endocrinol 358(1):135-43. doi: 10.1016/j.mce.2012.03.018. Epub 2012 Mar 29.
2012
|
| 62 | AKT1, MUL1
|
| Akt is negatively regulated by the MULAN E3 ligase.
|
| Bae S, Kim SY, Jung JH, Yoon Y, Cha HJ, Lee H, Kim K, Kim J, An IS, Kim J, Um HD, Park IC, Lee SJ, Nam SY, Jin YW, Lee JH, An S.
|
| Cell Res 22(5):873-85. doi: 10.1038/cr.2012.38. Epub 2012 Mar 13.
2012
|
| 63 | AKT1, TERT
|
| Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.
|
| Chung J, Khadka P, Chung IK.
|
| J Cell Sci 125(Pt 11):2684-97. doi: 10.1242/jcs.099267. Epub 2012 Feb 24.
2012
|
| 64 | AKT1, MTOR
|
| AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.
|
| Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB.
|
| Oncogene 31(15):1949-62. doi: 10.1038/onc.2011.394. Epub 2011 Sep 12.
2012
|
| 65 | AKT1, SSPN, UTRN
|
| Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration.
|
| Marshall JL, Holmberg J, Chou E, Ocampo AC, Oh J, Lee J, Peter AK, Martin PT, Crosbie-Watson RH.
|
| J Cell Biol 197(7):1009-27. doi: 10.1083/jcb.201110032.
2012
|
| 66 | AKT1, GSK3B, STYK1
|
| NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt.
|
| Li J, Wu F, Sheng F, Li YJ, Jin D, Ding X, Zhang S.
|
| FEBS Lett 586(21):3787-92. doi: 10.1016/j.febslet.2012.09.011. Epub 2012 Sep 23.
2012
|
| 67 | AKT1, DLX3
|
| Akt1 regulates phosphorylation and osteogenic activity of Dlx3.
|
| Choi YH, Choi HJ, Lee KY, Oh JW.
|
| Biochem Biophys Res Commun 425(4):800-5. doi: 10.1016/j.bbrc.2012.07.155.
2012
|
| 68 | AKT1, RUNX3
|
| RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.
|
| Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ.
|
| Oncogene 31(39):4302-16. doi: 10.1038/onc.2011.596.
2012
|
| 69 | AKT1, VIM
|
| Vimentin is a novel AKT1 target mediating motility and invasion.
|
| Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D.
|
| Oncogene 30(4):457-70. Epub 2010 Sep 20.
2011
|
| 70 | AKT1, MEN1
|
| The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
|
| Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, Agarwal SK, Marx SJ.
|
| Cancer Res 71(2):371-82. Epub 2010 Dec 2.
2011
|
| 71 | AKT1, FOXM1, NOTCH1
|
| Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.
|
| Wang Z, Li Y, Ahmad A, Banerjee S, Azmi AS, Kong D, Wojewoda C, Miele L, Sarkar FH.
|
| J Cell Biochem 112(1):78-88.
2011
|
| 72 | AKT1, PROTS
|
| A mosaic activating mutation in AKT1 associated with the Proteus syndrome.
|
| Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S, Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG.
|
| N Engl J Med 365(7):611-9. Epub 2011 Jul 27. 2011
|
| 73 | AKT1, TBK1, TICAM2
|
| Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
|
| Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY.
|
| J Immunol 186(1):499-507. Epub 2010 Nov 24.
2011
|
| 74 | AKT1, TBK1
|
| TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
|
| Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA.
|
| Mol Cell 41(4):458-70.
2011
|
| 75 | AKT1, AKT3
|
| Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
|
| Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA.
|
| Oncogene 30(15):1812-21. Epub 2011 Jan 17.
2011
|
| 76 | AKT1, CRTC2, PREX1
|
| Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
|
| Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Yun J, Shin HK, Song SH, Kim JH, Lee JS, Kim CD, Bae SS.
|
| Oncogene 30(26):2954-63. doi: 10.1038/onc.2011.22. Epub 2011 Feb 21.
2011
|
| 77 | AKT1, ATM, MRE11A, RNF168
|
| MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
|
| Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
|
| Cell Cycle 10(13):2218-32. Epub 2011 Jul 1.
2011
|
| 78 | AKT1
|
| AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
|
| Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.
|
| Cell 146(5):697-708. Erratum in: Cell. 2011 Sep 30;147(1):247. Schöll, Claudia [corrected to Scholl, Claudia].
2011
|
| 79 | AKT1, IKBKE, TBK1
|
| IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
|
| Guo JP, Coppola D, Cheng JQ.
|
| J Biol Chem 286(43):37389-98. doi: 10.1074/jbc.M111.287433. Epub 2011 Sep 9.
2011
|
| 80 | AKT1, IKBKE, TBK1
|
| IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
|
| Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL.
|
| Proc Natl Acad Sci U S A 108(16):6474-9. Epub 2011 Apr 4.
2011
|
| 81 | AJUBA, AKT1, PAK1
|
| Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.
|
| Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin-Martin B, Longmore G, Bailly M, Braga VM.
|
| J Cell Biol 195(5):855-71. doi: 10.1083/jcb.201107162. Epub 2011 Nov 21.
2011
|
| 82 | AKT1, TNFRSF4
|
| OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling.
|
| So T, Choi H, Croft M.
|
| J Immunol 186(6):3547-55. doi: 10.4049/jimmunol.1003156. Epub 2011 Feb 2.
2011
|
| 83 | AKT1
|
| Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells.
|
| Fortier AM, Van Themsche C, Asselin E, Cadrin M.
|
| FEBS Lett 584(5):984-8. Epub 2010 Jan 28.PMID: 20109457 2010
|
| 84 | AKT1, HNRNPA2B1
|
| Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.
|
| Guha M, Tang W, Sondheimer N, Avadhani NG.
|
| Biochim Biophys Acta iochim Biophys Acta. 2010 Feb 11. [Epub ahead of print]PMID: 20153290 2010
|
| 85 | AKT1, PTK6
|
| Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.
|
| Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.
|
| Mol Cell Biol 30(17):4280-92. Epub 2010 Jul 6.PMID: 20606012 2010
|
| 86 | AKT1, IQGAP1, MTOR
|
| IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.
|
| Chen F, Zhu HH, Zhou LF, Wu SS, Wang J, Chen Z.
|
| Exp Mol Med 42(7):477-83.PMID: 20530982 2010
|
| 87 | AKT1, RPS3
|
| Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair.
|
| Lee SB, Kwon IS, Park J, Lee KH, Ahn Y, Lee C, Kim J, Choi SY, Cho SW, Ahn JY.
|
| J Biol Chem 285(38):29457-68. Epub 2010 Jul 6.
2010
|
| 88 | AKT1, ZBTB42
|
| Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome.
|
| Harmon BT, Devaney SA, Gordish-Dressman H, Reeves EK, Zhao P, Devaney JM, Hoffman EP.
|
| Hum Genet 128(6):635-45. Epub 2010 Sep 26.
2010
|
| 89 | AKT1, ANXA2
|
| Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
|
| Su SC, Maxwell SA, Bayless KJ.
|
| J Biol Chem 285(52):40624-34. Epub 2010 Oct 13. 2010
|
| 90 | AKT1, CFLAR
|
| c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.
|
| Quintavalle C, Incoronato M, Puca L, Acunzo M, Zanca C, Romano G, Garofalo M, Iaboni M, Croce CM, Condorelli G.
|
| Cell Death Differ 17(12):1908-16. Epub 2010 May 28.
2010
|
| 91 | AKT1, AKT2, AKT3
|
| The Akt isoforms are present at distinct subcellular locations.
|
| Santi SA, Lee H.
|
| Am J Physiol Cell Physiol 298(3):C580-91. Epub 2009 Dec 16.
2010
|
| 92 | AKT1, CLK2
|
| Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.
|
| Nam SY, Seo HH, Park HS, An S, Kim JY, Yang KH, Kim CS, Jeong M, Jin YW.
|
| J Biol Chem 285(41):31157-63. doi: 10.1074/jbc.M110.122044. Epub 2010 Aug 3.
2010
|
| 93 | AKT1, MDM2, RAC1, SPRY2
|
| Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts.
|
| Lito P, Mets BD, Appledorn DM, Maher VM, McCormick JJ.
|
| J Biol Chem 284(2):848-54. Epub 2008 Nov 13.
2009
|
| 94 | AKT1, PLEKHM3
|
| Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
|
| Virtanen C, Paris J, Takahashi M.
|
| J Biol Chem 284(3):1636-43. Epub 2008 Nov 20. 2009
|
| 95 | AKT1, TRAF6
|
| The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
|
| Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK.
|
| Science 325(5944):1134-8.
2009
|
| 96 | AKT1, SLC9A1
|
| The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.
|
| Meima ME, Webb BA, Witkowska HE, Barber DL.
|
| J Biol Chem 284(39):26666-75. Epub 2009 Jul 21.PMID: 19622752 2009
|
| 97 | ACIN1, AKT1
|
| A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression.
|
| Park HS, Yun Y, Kim CS, Yang KH, Jeong M, Ahn SK, Jin YW, Nam SY.
|
| Eur J Cell Biol 88(10):563-75. Epub 2009 Jul 16.
2009
|
| 98 | APPL1, AKT1
|
| The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
|
| Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M.
|
| Cell 133(3):486-97. 2008
|
| 99 | AKT1, MAPK1, MAPK3, TGFB1, VEGFA, VEGFB, VEGFC
|
| Transforming growth factor-beta1 enhanced vascular endothelial growth factor synthesis in mesenchymal stem cells.
|
| Wang XJ, Dong Z, Zhong XH, Shi RZ, Huang SH, Lou Y, Li QP.
|
| Biochem Biophys Res Commun 365(3):548-54. Epub 2007 Nov 20. Erratum in: Biochem Biophys Res Commun. 2008 Aug 8;372(4):950.
2008
|
| 100 | AKT1, PAK4, RIOK3
|
| Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
|
| Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA.
|
| Proc Natl Acad Sci U S A 105(49):19372-7. Epub 2008 Dec 2.
2008
|
| 101 | AKT1, FSTL1
|
| Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart.
|
| Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K.
|
| Circulation 117(24):3099-108. Epub 2008 Jun 2.PMID: 18519848 2008
|
| 102 | AKAP5, AKT1, PRKACA, RAPGEF3
|
| Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.
|
| Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL.
|
| Cell Signal 20(10):1715-24. Epub 2008 May 16.
2008
|
| 103 | AKT1, BCL2L2
|
| Akt regulates drug-induced cell death through Bcl-w downregulation.
|
| Garofalo M, Quintavalle C, Zanca C, De Rienzo A, Romano G, Acunzo M, Puca L, Incoronato M, Croce CM, Condorelli G.
|
| PLoS One 3(12):e4070. doi: 10.1371/journal.pone.0004070. Epub 2008 Dec 30.
2008
|
| 104 | AKT1
|
| Real-time imaging nuclear translocation of Akt1 in HCC cells.
|
| Zhu L, Hu C, Li J, Xue P, He X, Ge C, Qin W, Yao G, Gu J.
|
| Biochem Biophys Res Commun 356(4):1038-43. Epub 2007 Mar 26. 2007
|
| 105 | AKT1,PTK2
|
| Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
|
| Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ.
|
| Cell Signal 19(4):761-71. Epub 2006 Nov 17. 2007
|
| 106 | AKT1,AKT2,CREB1
|
| Differential activation of CREB by Akt1 and Akt2.
|
| Kato S, Ding J, Du K.
|
| Biochem Biophys Res Commun 354(4):1061-6. Epub 2007 Jan 25. 2007
|
| 107 | AKT1, EEF1A2
|
| eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration.
|
| Amiri A, Noei F, Jeganathan S, Kulkarni G, Pinke DE, Lee JM.
|
| Oncogene 26(21):3027-40. Epub 2006 Nov 20.
2007
|
| 108 | AKT1, BCL2
|
| BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer.
|
| Mortenson MM, Galante JG, Gilad O, Schlieman MG, Virudachalam S, Kung HJ, Bold RJ.
|
| J Cell Biochem 102(5):1171-9.PMID: 17960583 2007
|
| 109 | AKT1, SETDB1
|
| Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.
|
| Gao H, Yu Z, Bi D, Jiang L, Cui Y, Sun J, Ma R.
|
| Mol Cell Biochem 305(1-2):35-44. Epub 2007 Jun 19.
2007
|
| 110 | AKT1, AKT2, AKT3
|
| Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
|
| Soung YH, Lee JW, Nam SW, Lee JY, Yoo NJ, Lee SH.
|
| Oncology 70(4):285-9. Epub 2006 Oct 16.
2006
|
| 111 | AKT1
|
| Identification of a tumour suppressor network opposing nuclear Akt function.
|
| Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP.
|
| Nature 441(7092):523-7. Epub 2006 May 7. 2006
|
| 112 | DTNBP1, NRG1, TAAR6, DTNBP1, COMT, RGS4, PPP3CC, ZDHHC8, AKT1, DAOA, G30
|
| Molecular genetic studies of schizophrenia.
|
| Riley B, Kendler KS.
|
| Eur J Hum Genet 14(6):669-80. 2006
|
| 113 | LRP2, AKT1
|
| PKB and megalin determine the survival or death of renal proximal tubule cells.
|
| Caruso-Neves C, Pinheiro AA, Cai H, Souza-Menezes J, Guggino WB.
|
| Proc Natl Acad Sci U S A 103(49):18810-5. Epub 2006 Nov 22. 2006
|
| 114 | AKT1
|
| Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.
|
| Gandy JC, Rountree AE, Bijur GN.
|
| FEBS Lett 580(13):3051-8. Epub 2006 Apr 27. 2006
|
| 115 | PRKCE, AKT1
|
| Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
|
| Lu D, Huang J, Basu A.
|
| J Biol Chem 281(32):22799-807. Epub 2006 Jun 19. 2006
|
| 116 | AKT1
|
| Molecular determinants of Akt-induced keratinocyte transformation.
|
| Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H, Garc’a-Escudero R, Mart’nez-Cruz AB, Mart’nez-Palacio J, Hern‡ndez P, Ballest’n C, Paramio JM.
|
| Oncogene 25(8):1174-85. 2006
|
| 117 | CARD11, AKT1
|
| CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.
|
| Narayan P, Holt B, Tosti R, Kane LP.
|
| Mol Cell Biol 26(6):2327-36. 2006
|
| 118 | EZH2, AKT1
|
| Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
|
| Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.
|
| Science 310(5746):306-10. 2005
|
| 119 | AKT1
|
| Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
|
| Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV.
|
| Nat Med 11(11):1188-96. Epub 2005 Oct 16. 2005
|
| 120 | AKT2, AKT1
|
| Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.
|
| Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS.
|
| J Cell Biol 171(6):1023-34. 2005
|
| 121 | GIT1, ARHGEF6, AKT1, PAK1, PAK2, PAK3
|
| A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
|
| Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF.
|
| J Neurosci 25(13):3379-88. 2005
|
| 122 | AKT1,STAT3
|
| Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
|
| Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ.
|
| J Biol Chem 280(47):38932-41. Epub 2005 Sep 20. 2005
|
| 123 | ACIN1, AKT1
|
| Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.
|
| Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K.
|
| EMBO J 24(20):3543-54. Epub 2005 Sep 22.
2005
|
| 124 | AKT1, GSK3B
|
| Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
|
| Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA.
|
| Nat Genet 36(2):131-7. Epub 2004 Jan 25. 2004
|
| 125 | AKT1, EIF4E, MTOR
|
| Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.
|
| Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW.
|
| Nature 428(6980):332-7. 2004
|
| 126 | AKT1, TCL1A
|
| Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
|
| Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA.
|
| Proc Natl Acad Sci U S A 99(22):14392-7. 2002
|
| 127 | GP6, AKT1
|
| Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI.
|
| Barry FA, Gibbins JM.
|
| J Biol Chem 277(15):12874-8. 2002
|
| 128 | AKT1, PKMYT1
|
| Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.
|
| Okumura E, Fukuhara T, Yoshida H, Hanada Si S, Kozutsumi R, Mori M, Tachibana K, Kishimoto T.
|
| Nat Cell Biol 4(2):111-6. 2002
|
| 129 | BMP2, AKT1
|
| Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.
|
| Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG.
|
| J Biol Chem 277(36):33361-8. Epub 2002 Jun 25. Erratum in: J Biol Chem. 2003 May 2;278(18):16452. 2002
|
| 130 | AKT1, NR4A1
|
| Akt phosphorylates and regulates the orphan nuclear receptor Nur77.
|
| Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y, Bichi R, Letofsky J, Croce CM.
|
| Proc Natl Acad Sci U S A 98(7):3690-4. 2001
|
| 131 | AKT1, AKT2, AKT3
|
| AKT plays a central role in tumorigenesis.
|
| Testa JR, Bellacosa A.
|
| Proc Natl Acad Sci U S A 98(20):10983-5. No abstract available. 2001
|
| 132 | AKT1, AKT2, AKT3, TCL1A, TCL1B
|
| The protooncogene TCL1 is an Akt kinase coactivator.
|
| Laine J, Kunstle G, Obata T, Sha M, Noguchi M.
|
| Mol Cell 6(2):395-407. 2000
|
| 133 | AKT1, PTEN
|
| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies.
|
| Dahia PLM, et al.
|
| Hum Mol Genet 8 : 185-193. 1999
|
| 134 | AKT1, AKT2, FOXO3, FOXO4
|
| Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
|
| Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME.
|
| Cell 96(6):857-68. 1999
|
| 135 | AKT1, AKT2, IGF1, IGF1R
|
| Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.
|
| Kulik G, et al.
|
| Mol Cell Biol 18(11):6711-8. 1998
|
| 136 | AKT1, AKT2
|
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
|
| Datta SR, et al.
|
| Cell 91(2):231-41. 1997
|
| 137 | AKT1, AKT2, PIK3CA
|
| The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
|
| Kennedy SG, et al.
|
| Genes Dev 11(6):701-13. 1997
|
| 138 | AKT1, AKT2, IL3, BAD
|
| Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
|
| del Peso L, et al.
|
| Science 278(5338):687-9. 1997
|
| 139 | AKT1
|
| Detailed physical mapping of probes in chromosome band 14q32 reveals a high recombination rate at the subtelomeric region.
|
| Hofker MH, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1014. 1989
|
| 140 | AKT1
|
| The AKT1 proto-oncogene maps to human chromosome 14, band q32.
|
| Staal SP, et al.
|
| Genomics 2 : 96-98. 1988
|
| 141 | AKT1
|
| The AKT1 gene, the human homologue of a retroviral oncogene, is located on chromosome 14 at band q32.
|
| Testa JR, et al.
|
| (HGM8) Cytogenet Cell Genet 40 : 761. 1985
|