Citations for
1AKT1, CASTOR1, MTOR, RNF167
RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Li T, Wang X, Ju E, da Silva SR, Chen L, Zhang X, Wei S, Gao SJ.
Nat Commun. Feb 16;12(1):1055. doi: 10.1038/s41467-021-21206-3. 2021
2AKT1, FSCN1, HBEGF, SOX2
SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF
Xiao W, Zheng S, Xie X, Li X, Zhang L, Yang A, Wang J, Tang H, Xie X.
Mol Ther Oncolytics. Mar 13;17:118-129. doi: 10.1016/j.omto.2020.03.001. 2020
3AKT1, TIGAR
TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma.
Tang Z, He Z.
Oncol Lett 18(3):2509-2517. doi: 10.3892/ol.2019.10574. Epub 2019 Jul 5. 2019
4AKT1, CDH1, DSC3
Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.
Cui T, Yang L, Ma Y, Petersen I, Chen Y.
Exp Cell Res 378(2):124-130. doi: 10.1016/j.yexcr.2019.03.015. Epub 2019 Mar 8. 2019
5AKT1, SAV1
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, Kim WY, Earp HS, Liu P.
Nat Commun. Apr 3;10(1):1515. doi: 10.1038/s41467-019-09233-7. 2019
6AKT1, HDAC3, PDCD5
Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Lee SH, Seo J, Park SY, Jeong MH, Choi HK, Lee CJ, Kim MJ, Guk G, Lee S, Park H, Jeong JW, Ha CH, Park S, Yoon HG.
Proc Natl Acad Sci U S A 115(18):4672-4677. doi: 10.1073/pnas.1712918115. Epub 2018 Mar 27. 2018
7AKT1, EPS8L3, FOXO1
Overexpression of EPS8L3 promotes cell proliferation by inhibiting the transactivity of FOXO1 in HCC.
Zeng CX, Tang LY, Xie CY, Li FX, Zhao JY, Jiang N, Tong Z, Fu SB, Wen FJ, Feng WS.
Neoplasma 65(5):701-707. doi: 10.4149/neo_2018_170725N503. Epub 2018 Jun 17. 2018
8AKT1, AKT2, VRK2
Functional characterization of lysosomal interaction of Akt with VRK2.
Hirata N, Suizu F, Matsuda-Lennikov M, Tanaka T, Edamura T, Ishigaki S, Donia T, Lithanatudom P, Obuse C, Iwanaga T, Noguchi M.
Oncogene Oct;37(40):5367-5386. doi: 10.1038/s41388-018-0330-0. Epub 2018 Jun 5. 2018
9AIPL1, AKT1, DIAPH2, ZP3
ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis.
Gao LL, Zhou CX, Zhang XL, Liu P, Jin Z, Zhu GY, Ma Y, Li J, Yang ZX, Zhang D.
Sci Rep 7:41272. doi: 10.1038/srep41272. 2017
10AKT1, TRIM14
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
Xu G, Guo Y, Xu D, Wang Y, Shen Y, Wang F, Lv Y, Song F, Jiang D, Zhang Y, Lou Y, Meng Y, Yang Y, Kang Y.
Sci Rep 7:42411. doi: 10.1038/srep42411. 2017
11AKT1, ERBB2
The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.
Mathavan K, Khedgikar V, Bartolo V, Alfandari D.
PLoS One 12(11):e0188963. doi: 10.1371/journal.pone.0188963. eCollection 2017. 2017
12AKT1, FOXO3, MUL1
FOXO3 induces ubiquitylation of AKT through MUL1 regulation.
Kim SY, Kim HJ, Byeon HK, Kim DH, Kim CH.
Oncotarget 8(66):110474-110489. doi: 10.18632/oncotarget.22793. eCollection 2017 Dec 15. 2017
13AKT1, MAPK14, TNFAIP8L2
TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways.
Zhang Z, Liu L, Liu C, Cao S, Zhu Y, Mei Q.
Oncol Rep 36(6):3311-3316. doi: 10.3892/or.2016.5192. 2016
14AKT1, SMYD3
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
Yoshioka Y, Suzuki T, Matsuo Y, Nakakido M, Tsurita G, Simone C, Watanabe T, Dohmae N, Nakamura Y, Hamamoto R.
Oncotarget 7(46):75023-75037. doi: 10.18632/oncotarget.11898. 2016
15AKT1, FKBP5
A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies.
Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L.
Psychoneuroendocrinology 52:43-58. doi: 10.1016/j.psyneuen.2014.11.005. Epub 2014 Nov 11. 2015
16AKT1, SGK1
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.
Satoh N, Nakamura M, Suzuki M, Suzuki A, Seki G, Horita S.
Biomed Res Int 2015:971697. doi: 10.1155/2015/971697. Epub 2015 Sep 28. Review. 2015
17AKT1, CCDC88A
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, Ichihara S, Furukawa K, Maeda K, Murohara T, Takahashi M.
Cancer Res 75(5):813-23. doi: 10.1158/0008-5472.CAN-14-1317. 2015
18AKT1, MAPK14, NFKBIA, TNFAIP8L2
TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression.
Liu QQ, Zhang FF, Wang F, Qiu JH, Luo CH, Zhu GY, Liu YF.
PLoS One 10(5):e0126176. doi: 10.1371/journal.pone.0126176. 2015
19AKT1, PDE3B
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin.
DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ.
Mol Cell Biol 35(16):2752-60. doi: 10.1128/MCB.00422-15. Epub 2015 Jun 1. 2015
20AKT1, GSK3B, ZNRF1
Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
Wakatsuki S, Furuno A, Ohshima M, Araki T.
J Cell Biol 211(4):881-96. doi: 10.1083/jcb.201506102. Epub 2015 Nov 16. 2015
21AKT1, IFNA1, IL2, IL7
Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
Nguyen TP, Bazdar DA, Mudd JC, Lederman MM, Harding CV, Hardy GA, Sieg SF.
J Leukoc Biol 97(6):1139-46. doi: 10.1189/jlb.4A0714-345RR. Epub 2015 Mar 17. 2015
22AKT1, BCL2L12, CD82, STAT5A
The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells.
Nishioka C, Ikezoe T, Takeuchi A, Nobumoto A, Tsuda M, Yokoyama A.
Leukemia 29(12):2296-306. doi: 10.1038/leu.2015.219. Epub 2015 Aug 11. 2015
23AKT1
Significance of Akt activation and AKT gene increases in soft tissue tumors.
Dobashi Y, Sato E, Oda Y, Inazawa J, Ooi A.
Hum Pathol 45(1):127-36. doi: 10.1016/j.humpath.2013.06.024. 2014
24AKT1, CARD11
Phosphorylation of Carma1, but not Bcl10, by Akt regulates TCR/CD28-mediated NF-κB induction and cytokine production.
Cheng J, Hamilton KS, Kane LP.
Mol Immunol 59(1):110-6. doi: 10.1016/j.molimm.2014.01.011. Epub 2014 Feb 16. 2014
25AKT1, FAM3A, PIK3CA
FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis.
Wang C, Chi Y, Li J, Miao Y, Li S, Su W, Jia S, Chen Z, Du S, Zhang X, Zhou Y, Wu W, Zhu M, Wang Z, Yang H, Xu G, Wang S, Yang J, Guan Y.
Hepatology 59(5):1779-90. doi: 10.1002/hep.26945. Epub 2014 Mar 27. 2014
26AKT1, AKT2
Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.
Am J Physiol Renal Physiol 307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24. 2014
27AKT1, AKT2, AKT3
Differential effects of Akt isoforms on somatic cell reprogramming.
Tang Y, Jiang Z, Luo Y, Zhao X, Wang L, Norris C, Tian XC.
J Cell Sci 127(Pt 18):3998-4008. doi: 10.1242/jcs.150029. Epub 2014 Jul 18. 2014
28AKT1, AKT2, CK2
Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.
Girardi C, James P, Zanin S, Pinna LA, Ruzzene M.
Biochim Biophys Acta 1843(9):1865-74. doi: 10.1016/j.bbamcr.2014.04.020. Epub 2014 Apr 24. 2014
29AKT1, AKT2, CSNK2A1
Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.
Girardi C, James P, Zanin S, Pinna LA, Ruzzene M.
Biochim Biophys Acta 1843(9):1865-74. doi: 10.1016/j.bbamcr.2014.04.020. Epub 2014 Apr 24. 2014
30AKT1, AKT2, DAB2
Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.
Am J Physiol Renal Physiol 307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24. 2014
31AKT1, MC1R, POMC
Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling.
Cheng LB, Cheng L, Bi HE, Zhang ZQ, Yao J, Zhou XZ, Jiang Q.
Biochem Biophys Res Commun 443(2):447-52. doi: 10.1016/j.bbrc.2013.11.113. Epub 2013 Dec 6. 2014
32AKT1, TKT
Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis.
Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR.
Mol Cell 55(2):264-76. doi: 10.1016/j.molcel.2014.05.028. Epub 2014 Jun 26. 2014
33AKT1, ALCAM, FOXO1
CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition of FOXO proteins through AKT.
Yu W, Wang J, Ma L, Tang X, Qiao Y, Pan Q, Yu Y, Sun F.
Oncol Rep 32(2):677-83. doi: 10.3892/or.2014.3226. Epub 2014 May 30. 2014
34AKT1, PIK3CA
Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes.
Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C.
Am J Hum Genet 92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13. 2013
35AKT1, LMNA
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression.
Bertacchini J, Beretti F, Cenni V, Guida M, Gibellini F, Mediani L, Marin O, Maraldi NM, de Pol A, Lattanzi G, Cocco L, Marmiroli S.
FASEB J ASEB J. 2013 Feb 21. [Epub ahead of print] 2013
36AKT1, SMO
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R.
Nat Genet 45(3):285-9. doi: 10.1038/ng.2526. Epub 2013 Jan 20. 2013
37AKT1, PHF20
PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J.
Cell Signal 25(1):74-84. doi: 10.1016/j.cellsig.2012.09.009. Epub 2012 Sep 11. 2013
38AKT1, JADE1
Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.
Zeng L, Bai M, Mittal AK, El-Jouni W, Zhou J, Cohen DM, Zhou MI, Cohen HT.
Cancer Res 73(17):5371-80. doi: 10.1158/0008-5472.CAN-12-4707. Epub 2013 Jul 1. 2013
39AKT1, ARHGEF3, CRTC2
XPLN is an endogenous inhibitor of mTORC2.
Khanna N, Fang Y, Yoon MS, Chen J.
Proc Natl Acad Sci U S A 110(40):15979-84. doi: 10.1073/pnas.1310434110. Epub 2013 Sep 16. 2013
40AKT1, AKT2, PDPK1
PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
Tsuchiya A, Kanno T, Nishizaki T.
J Endocrinol 220(1):49-59. doi: 10.1530/JOE-13-0172. Print 2014 Jan. 2013
41AKT1
Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
Abdalla M, Goc A, Segar L, Somanath PR.
J Biol Chem 288(46):33483-93. doi: 10.1074/jbc.M113.504290. Epub 2013 Oct 8. 2013
42AKT1
Akt SUMOylation regulates cell proliferation and tumorigenesis.
Li R, Wei J, Jiang C, Liu D, Deng L, Zhang K, Wang P.
Cancer Res 73(18):5742-53. doi: 10.1158/0008-5472.CAN-13-0538. Epub 2013 Jul 24. 2013
43AKT1, MTOR
Akt/mTOR signalling in myelination.
Norrmén C, Suter U.
Biochem Soc Trans 41(4):944-50. doi: 10.1042/BST20130046. Review. 2013
44AKT1, PIKFYVE
AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J.
Sci Signal 6(279):ra45. doi: 10.1126/scisignal.2004015. 2013
45AKT1
Akt1 as a putative regulator of Hox genes.
Kong KA, Yoon H, Kim MH.
Gene 513(2):287-91. doi: 10.1016/j.gene.2012.10.034. Epub 2012 Nov 12. 2013
46AKT1
AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
Nygaard M, Soerensen M, Flachsbart F, Mengel-From J, Tan Q, Schreiber S, Nebel A, Christensen K, Christiansen L.
Eur J Hum Genet 21(5):574-7. doi: 10.1038/ejhg.2012.196. Epub 2012 Aug 29. 2013
47AKT1, MTOR, PIK3CA
The PI3K/AKT/mTOR signaling pathway is overactivated in primary aldosteronism.
Su H, Gu Y, Li F, Wang Q, Huang B, Jin X, Ning G, Sun F.
PLoS One 8(4):e62399. doi: 10.1371/journal.pone.0062399. Print 2013. 2013
48ACTA2, AKT1
Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
Abdalla M, Goc A, Segar L, Somanath PR.
J Biol Chem 288(46):33483-93. doi: 10.1074/jbc.M113.504290. Epub 2013 Oct 8. 2013
49AKT1, CWS6
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C.
Am J Hum Genet 92(1):76-80. doi: 10.1016/j.ajhg.2012.10.021. Epub 2012 Dec 13. 2013
50AKT1, TPP1
Akt regulates TPP1 homodimerization and telomere protection.
Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z.
Aging Cell 12(6):1091-9. doi: 10.1111/acel.12137. Epub 2013 Aug 11. 2013
51AKT1, RIPK1
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A.
PLoS One 8(3):e56576. doi: 10.1371/journal.pone.0056576. Epub 2013 Mar 1. 2013
52AKT1, SDC4
Syndecan 4 regulation of PDK1-dependent Akt activation.
Ju R, Simons M.
Cell Signal 25(1):101-5. doi: 10.1016/j.cellsig.2012.09.007. Epub 2012 Sep 10. 2013
53AKT1, PHF20
Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.
Park S, Kim D, Dan HC, Chen H, Testa JR, Cheng JQ.
J Biol Chem 287(14):11151-63. doi: 10.1074/jbc.M111.333922. Epub 2012 Feb 14. 2012
54AKT1
The role of Akt signalling in the mammalian ovary.
Cecconi S, Mauro A, Cellini V, Patacchiola F.
Int J Dev Biol 56(10-12):809-17. doi: 10.1387/ijdb.120146sc. Review. 2012
55AKT1, AKT2
Molecular alterations in AKT and its protein activation in human lung carcinomas.
Dobashi Y, Kimura M, Matsubara H, Endo S, Inazawa J, Ooi A.
Hum Pathol 43(12):2229-40. doi: 10.1016/j.humpath.2012.03.015. Epub 2012 Jun 28. 2012
56AKT1, PROM1
CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma.
Kimura T, Wang L, Tabu K, Nishihara H, Mashita Y, Kikuchi N, Tanino M, Hiraga H, Tanaka S.
Cancer Invest 30(5):390-7. doi: 10.3109/07357907.2012.672607. 2012
57AKT1, IGF2
Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Kent LN, Ohboshi S, Soares MJ.
Int J Dev Biol 56(4):255-61. doi: 10.1387/ijdb.113407lk. 2012
58AKT1, CYLD
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt.
Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD.
Nat Commun 3:771. doi: 10.1038/ncomms1776. 2012
59AKT1, AKT2
Differential function of Akt1 and Akt2 in human adipocytes.
Fischer-Posovszky P, Tews D, Horenburg S, Debatin KM, Wabitsch M.
Mol Cell Endocrinol 358(1):135-43. doi: 10.1016/j.mce.2012.03.018. Epub 2012 Mar 29. 2012
60AKT1, MUL1
Akt is negatively regulated by the MULAN E3 ligase.
Bae S, Kim SY, Jung JH, Yoon Y, Cha HJ, Lee H, Kim K, Kim J, An IS, Kim J, Um HD, Park IC, Lee SJ, Nam SY, Jin YW, Lee JH, An S.
Cell Res 22(5):873-85. doi: 10.1038/cr.2012.38. Epub 2012 Mar 13. 2012
61AKT1, TERT
Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.
Chung J, Khadka P, Chung IK.
J Cell Sci 125(Pt 11):2684-97. doi: 10.1242/jcs.099267. Epub 2012 Feb 24. 2012
62AKT1, MTOR
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.
Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB.
Oncogene 31(15):1949-62. doi: 10.1038/onc.2011.394. Epub 2011 Sep 12. 2012
63AKT1, SSPN, UTRN
Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration.
Marshall JL, Holmberg J, Chou E, Ocampo AC, Oh J, Lee J, Peter AK, Martin PT, Crosbie-Watson RH.
J Cell Biol 197(7):1009-27. doi: 10.1083/jcb.201110032. 2012
64AKT1, GSK3B, STYK1
NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt.
Li J, Wu F, Sheng F, Li YJ, Jin D, Ding X, Zhang S.
FEBS Lett 586(21):3787-92. doi: 10.1016/j.febslet.2012.09.011. Epub 2012 Sep 23. 2012
65AKT1, DLX3
Akt1 regulates phosphorylation and osteogenic activity of Dlx3.
Choi YH, Choi HJ, Lee KY, Oh JW.
Biochem Biophys Res Commun 425(4):800-5. doi: 10.1016/j.bbrc.2012.07.155. 2012
66AKT1, RUNX3
RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.
Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ.
Oncogene 31(39):4302-16. doi: 10.1038/onc.2011.596. 2012
67AKT1, VIM
Vimentin is a novel AKT1 target mediating motility and invasion.
Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D.
Oncogene 30(4):457-70. Epub 2010 Sep 20. 2011
68AKT1, MEN1
The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, Agarwal SK, Marx SJ.
Cancer Res 71(2):371-82. Epub 2010 Dec 2. 2011
69AKT1, FOXM1, NOTCH1
Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.
Wang Z, Li Y, Ahmad A, Banerjee S, Azmi AS, Kong D, Wojewoda C, Miele L, Sarkar FH.
J Cell Biochem 112(1):78-88. 2011
70AKT1, PROTS
A mosaic activating mutation in AKT1 associated with the Proteus syndrome.
Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S, Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG.
N Engl J Med 365(7):611-9. Epub 2011 Jul 27. 2011
71AKT1, TBK1, TICAM2
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY.
J Immunol 186(1):499-507. Epub 2010 Nov 24. 2011
72AKT1, TBK1
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T, Tan SL, White MA.
Mol Cell 41(4):458-70. 2011
73AKT1, AKT3
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA.
Oncogene 30(15):1812-21. Epub 2011 Jan 17. 2011
74AKT1, CRTC2, PREX1
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Yun J, Shin HK, Song SH, Kim JH, Lee JS, Kim CD, Bae SS.
Oncogene 30(26):2954-63. doi: 10.1038/onc.2011.22. Epub 2011 Feb 21. 2011
75AKT1, ATM, MRE11A, RNF168
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
Cell Cycle 10(13):2218-32. Epub 2011 Jul 1. 2011
76AKT1
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.
Cell 146(5):697-708. Erratum in: Cell. 2011 Sep 30;147(1):247. Schöll, Claudia [corrected to Scholl, Claudia]. 2011
77AKT1, IKBKE, TBK1
IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
Guo JP, Coppola D, Cheng JQ.
J Biol Chem 286(43):37389-98. doi: 10.1074/jbc.M111.287433. Epub 2011 Sep 9. 2011
78AKT1, IKBKE, TBK1
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL.
Proc Natl Acad Sci U S A 108(16):6474-9. Epub 2011 Apr 4. 2011
79AJUBA, AKT1, PAK1
Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.
Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin-Martin B, Longmore G, Bailly M, Braga VM.
J Cell Biol 195(5):855-71. doi: 10.1083/jcb.201107162. Epub 2011 Nov 21. 2011
80AKT1, TNFRSF4
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling.
So T, Choi H, Croft M.
J Immunol 186(6):3547-55. doi: 10.4049/jimmunol.1003156. Epub 2011 Feb 2. 2011
81AKT1
Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells.
Fortier AM, Van Themsche C, Asselin E, Cadrin M.
FEBS Lett 584(5):984-8. Epub 2010 Jan 28.PMID: 20109457 2010
82AKT1, HNRNPA2B1
Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.
Guha M, Tang W, Sondheimer N, Avadhani NG.
Biochim Biophys Acta iochim Biophys Acta. 2010 Feb 11. [Epub ahead of print]PMID: 20153290 2010
83AKT1, PTK6
Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.
Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.
Mol Cell Biol 30(17):4280-92. Epub 2010 Jul 6.PMID: 20606012 2010
84AKT1, IQGAP1, MTOR
IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.
Chen F, Zhu HH, Zhou LF, Wu SS, Wang J, Chen Z.
Exp Mol Med 42(7):477-83.PMID: 20530982 2010
85AKT1, RPS3
Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair.
Lee SB, Kwon IS, Park J, Lee KH, Ahn Y, Lee C, Kim J, Choi SY, Cho SW, Ahn JY.
J Biol Chem 285(38):29457-68. Epub 2010 Jul 6. 2010
86AKT1, ZBTB42
Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome.
Harmon BT, Devaney SA, Gordish-Dressman H, Reeves EK, Zhao P, Devaney JM, Hoffman EP.
Hum Genet 128(6):635-45. Epub 2010 Sep 26. 2010
87AKT1, ANXA2
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
Su SC, Maxwell SA, Bayless KJ.
J Biol Chem 285(52):40624-34. Epub 2010 Oct 13. 2010
88AKT1, CFLAR
c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.
Quintavalle C, Incoronato M, Puca L, Acunzo M, Zanca C, Romano G, Garofalo M, Iaboni M, Croce CM, Condorelli G.
Cell Death Differ 17(12):1908-16. Epub 2010 May 28. 2010
89AKT1, AKT2, AKT3
The Akt isoforms are present at distinct subcellular locations.
Santi SA, Lee H.
Am J Physiol Cell Physiol 298(3):C580-91. Epub 2009 Dec 16. 2010
90AKT1, CLK2
Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.
Nam SY, Seo HH, Park HS, An S, Kim JY, Yang KH, Kim CS, Jeong M, Jin YW.
J Biol Chem 285(41):31157-63. doi: 10.1074/jbc.M110.122044. Epub 2010 Aug 3. 2010
91AKT1, MDM2, RAC1, SPRY2
Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts.
Lito P, Mets BD, Appledorn DM, Maher VM, McCormick JJ.
J Biol Chem 284(2):848-54. Epub 2008 Nov 13. 2009
92AKT1, PLEKHM3
Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
Virtanen C, Paris J, Takahashi M.
J Biol Chem 284(3):1636-43. Epub 2008 Nov 20. 2009
93AKT1, TRAF6
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK.
Science 325(5944):1134-8. 2009
94AKT1, SLC9A1
The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.
Meima ME, Webb BA, Witkowska HE, Barber DL.
J Biol Chem 284(39):26666-75. Epub 2009 Jul 21.PMID: 19622752 2009
95ACIN1, AKT1
A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression.
Park HS, Yun Y, Kim CS, Yang KH, Jeong M, Ahn SK, Jin YW, Nam SY.
Eur J Cell Biol 88(10):563-75. Epub 2009 Jul 16. 2009
96APPL1, AKT1
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M.
Cell 133(3):486-97. 2008
97AKT1, MAPK1, MAPK3, TGFB1, VEGFA, VEGFB, VEGFC
Transforming growth factor-beta1 enhanced vascular endothelial growth factor synthesis in mesenchymal stem cells.
Wang XJ, Dong Z, Zhong XH, Shi RZ, Huang SH, Lou Y, Li QP.
Biochem Biophys Res Commun 365(3):548-54. Epub 2007 Nov 20. Erratum in: Biochem Biophys Res Commun. 2008 Aug 8;372(4):950. 2008
98AKT1, PAK4, RIOK3
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA.
Proc Natl Acad Sci U S A 105(49):19372-7. Epub 2008 Dec 2. 2008
99AKT1, FSTL1
Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart.
Oshima Y, Ouchi N, Sato K, Izumiya Y, Pimentel DR, Walsh K.
Circulation 117(24):3099-108. Epub 2008 Jun 2.PMID: 18519848 2008
100AKAP5, AKT1, PRKACA, RAPGEF3
Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.
Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL.
Cell Signal 20(10):1715-24. Epub 2008 May 16. 2008
101AKT1, BCL2L2
Akt regulates drug-induced cell death through Bcl-w downregulation.
Garofalo M, Quintavalle C, Zanca C, De Rienzo A, Romano G, Acunzo M, Puca L, Incoronato M, Croce CM, Condorelli G.
PLoS One 3(12):e4070. doi: 10.1371/journal.pone.0004070. Epub 2008 Dec 30. 2008
102AKT1
Real-time imaging nuclear translocation of Akt1 in HCC cells.
Zhu L, Hu C, Li J, Xue P, He X, Ge C, Qin W, Yao G, Gu J.
Biochem Biophys Res Commun 356(4):1038-43. Epub 2007 Mar 26. 2007
103AKT1,PTK2
Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ.
Cell Signal 19(4):761-71. Epub 2006 Nov 17. 2007
104AKT1,AKT2,CREB1
Differential activation of CREB by Akt1 and Akt2.
Kato S, Ding J, Du K.
Biochem Biophys Res Commun 354(4):1061-6. Epub 2007 Jan 25. 2007
105AKT1, EEF1A2
eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration.
Amiri A, Noei F, Jeganathan S, Kulkarni G, Pinke DE, Lee JM.
Oncogene 26(21):3027-40. Epub 2006 Nov 20. 2007
106AKT1, BCL2
BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer.
Mortenson MM, Galante JG, Gilad O, Schlieman MG, Virudachalam S, Kung HJ, Bold RJ.
J Cell Biochem 102(5):1171-9.PMID: 17960583 2007
107AKT1, SETDB1
Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.
Gao H, Yu Z, Bi D, Jiang L, Cui Y, Sun J, Ma R.
Mol Cell Biochem 305(1-2):35-44. Epub 2007 Jun 19. 2007
108AKT1, AKT2, AKT3
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
Soung YH, Lee JW, Nam SW, Lee JY, Yoo NJ, Lee SH.
Oncology 70(4):285-9. Epub 2006 Oct 16. 2006
109AKT1
Identification of a tumour suppressor network opposing nuclear Akt function.
Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP.
Nature 441(7092):523-7. Epub 2006 May 7. 2006
110DTNBP1, NRG1, TAAR6, DTNBP1, COMT, RGS4, PPP3CC, ZDHHC8, AKT1, DAOA, G30
Molecular genetic studies of schizophrenia.
Riley B, Kendler KS.
Eur J Hum Genet 14(6):669-80. 2006
111LRP2, AKT1
PKB and megalin determine the survival or death of renal proximal tubule cells.
Caruso-Neves C, Pinheiro AA, Cai H, Souza-Menezes J, Guggino WB.
Proc Natl Acad Sci U S A 103(49):18810-5. Epub 2006 Nov 22. 2006
112AKT1
Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.
Gandy JC, Rountree AE, Bijur GN.
FEBS Lett 580(13):3051-8. Epub 2006 Apr 27. 2006
113PRKCE, AKT1
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
Lu D, Huang J, Basu A.
J Biol Chem 281(32):22799-807. Epub 2006 Jun 19. 2006
114AKT1
Molecular determinants of Akt-induced keratinocyte transformation.
Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H, Garc’a-Escudero R, Mart’nez-Cruz AB, Mart’nez-Palacio J, Hern‡ndez P, Ballest’n C, Paramio JM.
Oncogene 25(8):1174-85. 2006
115CARD11, AKT1
CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.
Narayan P, Holt B, Tosti R, Kane LP.
Mol Cell Biol 26(6):2327-36. 2006
116EZH2, AKT1
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.
Science 310(5746):306-10. 2005
117AKT1
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV.
Nat Med 11(11):1188-96. Epub 2005 Oct 16. 2005
118AKT2, AKT1
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS.
J Cell Biol 171(6):1023-34. 2005
119GIT1, ARHGEF6, AKT1, PAK1, PAK2, PAK3
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF.
J Neurosci 25(13):3379-88. 2005
120AKT1,STAT3
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ.
J Biol Chem 280(47):38932-41. Epub 2005 Sep 20. 2005
121ACIN1, AKT1
Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.
Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K.
EMBO J 24(20):3543-54. Epub 2005 Sep 22. 2005
122AKT1, GSK3B
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA.
Nat Genet 36(2):131-7. Epub 2004 Jan 25. 2004
123AKT1, EIF4E, MTOR
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.
Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW.
Nature 428(6980):332-7. 2004
124AKT1, TCL1A
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA.
Proc Natl Acad Sci U S A 99(22):14392-7. 2002
125GP6, AKT1
Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI.
Barry FA, Gibbins JM.
J Biol Chem 277(15):12874-8. 2002
126AKT1, PKMYT1
Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.
Okumura E, Fukuhara T, Yoshida H, Hanada Si S, Kozutsumi R, Mori M, Tachibana K, Kishimoto T.
Nat Cell Biol 4(2):111-6. 2002
127BMP2, AKT1
Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.
Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG.
J Biol Chem 277(36):33361-8. Epub 2002 Jun 25. Erratum in: J Biol Chem. 2003 May 2;278(18):16452. 2002
128AKT1, NR4A1
Akt phosphorylates and regulates the orphan nuclear receptor Nur77.
Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y, Bichi R, Letofsky J, Croce CM.
Proc Natl Acad Sci U S A 98(7):3690-4. 2001
129AKT1, AKT2, AKT3
AKT plays a central role in tumorigenesis.
Testa JR, Bellacosa A.
Proc Natl Acad Sci U S A 98(20):10983-5. No abstract available. 2001
130AKT1, AKT2, AKT3, TCL1A, TCL1B
The protooncogene TCL1 is an Akt kinase coactivator.
Laine J, Kunstle G, Obata T, Sha M, Noguchi M.
Mol Cell 6(2):395-407. 2000
131AKT1, PTEN
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies.
Dahia PLM, et al.
Hum Mol Genet 8 : 185-193. 1999
132AKT1, AKT2, FOXO3, FOXO4
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME.
Cell 96(6):857-68. 1999
133AKT1, AKT2, IGF1, IGF1R
Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.
Kulik G, et al.
Mol Cell Biol 18(11):6711-8. 1998
134AKT1, AKT2
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
Datta SR, et al.
Cell 91(2):231-41. 1997
135AKT1, AKT2, PIK3CA
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
Kennedy SG, et al.
Genes Dev 11(6):701-13. 1997
136AKT1, AKT2, IL3, BAD
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
del Peso L, et al.
Science 278(5338):687-9. 1997
137AKT1
Detailed physical mapping of probes in chromosome band 14q32 reveals a high recombination rate at the subtelomeric region.
Hofker MH, et al.
(HGM10) Cytogenet Cell Genet 51 : 1014. 1989
138AKT1
The AKT1 proto-oncogene maps to human chromosome 14, band q32.
Staal SP, et al.
Genomics 2 : 96-98. 1988
139AKT1
The AKT1 gene, the human homologue of a retroviral oncogene, is located on chromosome 14 at band q32.
Testa JR, et al.
(HGM8) Cytogenet Cell Genet 40 : 761. 1985