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FLASH GENE
Symbol AK2 contributors: mct - updated : 18-03-2009
HGNC name adenylate kinase 2
HGNC id 362
Corresponding disease
RTDG reticular dysgenesis
Location 1p35.1      Physical location : 33.473.585 - 33.502.492
Synonym name
  • ATP-AMP transphosphorylase
  • adenylate kinase isoenzyme 2, mitochondrial
  • Synonym symbol(s) ADK2
    EC.number 2.7.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 28.90 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC1203 1p36.11-p34.2 hypothetical protein MGC1203 FLJ10547 1p36.11-p34.2 hypothetical protein FLJ10547 RP4-622L5 1p36.11-p34.2 hypothetical protein RP4-622L5 EIF3S2 1p34.1 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa LOC339483 1p34.3 hypothetical protein LOC339483 MGC10820 1p34.3 hypothetical protein MGC10820 LCK 1p35.1 lymphocyte-specific protein tyrosine kinase HDAC1 1p34.3 histone deacetylase 1 MLP 1p34 MARCKS-like protein STK22C 1p34-p35 serine/threonine kinase 22C (spermiogenesis associated) FLJ10276 1p34.3 hypothetical protein FLJ10276 LOC343338 1p34.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ZBTB8 1p34.3 zinc finger and BTB domain containing 8 ARCH 1p34.3 archease RBBP4 1p34.3 retinoblastoma binding protein 4 SYNCOILIN 1p34.3-p33 retinoblastoma binding protein 4 KIAA1522 1p34.3 KIAA1522 protein YARS 1p34.3 tyrosyl-tRNA synthetase FLJ12903 1p34.3 hypothetical protein FLJ12903 FRCP2 HPCA 1p35-p34.2 hippocalcin BCLP 1p35-p34 beta-casein-like protein FLJ90005 1p34.3 hypothetical protein FLJ90005 LOC127545 1p34.3 similar to ribosomal protein L18a; 60S ribosomal protein L18a AK2 1p34 adenylate kinase 2 ODC-p  ornithine decarboxylase-like FLJ10759 1p34.3 hypothetical protein FLJ10759 FLJ25476 1p34.3 FLJ25476 protein LOC127550 1p34.3 similar to iGb3 synthase PHC2 1p34.3 polyhomeotic-like 2 (Drosophila) ZNF31 1p34.3 zinc finger protein 31 (KOX 29) CSMD2 1p34.3 CUB and Sushi multiple domains 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 961 26.5 239 - 2009 19043417
    7 - 3606 25.5 232 major form 2009 19043417
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestiveliver   highly Homo sapiens
    Hearing/Equilibriumearinner    Homo sapiens
    Lymphoid/Immunespleen     Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Lymphoid/Immunelymphocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • adenylate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    basic FUNCTION
  • adenylate kinase 2 implicated in adenine and guanine nucleotide pool homeostasis
  • regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides
  • mitochondrial energy metabolism enzyme, that catalyzes the reversible transfer of a phosphoryl group from ATP to AMP
  • may be playing a role in providing the energy required for the proliferation of hematopoietic precursors and/or in controlling cell apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
  • AK2/FADD/caspase-10 (AFAC10) complex, mediating an amplification loop that ensures the execution of the intrinsic apoptosis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RTDG
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS