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FLASH GENE
Symbol AK2 contributors: mct - updated : 18-03-2009
HGNC name adenylate kinase 2
HGNC id 362
DNA
TYPE functioning gene
STRUCTURE 28.90 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 961 26.5 239 - 2009 19043417
7 - 3606 25.5 232 major form 2009 19043417
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Digestiveliver   highly Homo sapiens
Hearing/Equilibriumearinner    Homo sapiens
Lymphoid/Immunespleen     Homo sapiens
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • adenylate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    basic FUNCTION
  • adenylate kinase 2 implicated in adenine and guanine nucleotide pool homeostasis
  • regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides
  • mitochondrial energy metabolism enzyme, that catalyzes the reversible transfer of a phosphoryl group from ATP to AMP
  • may be playing a role in providing the energy required for the proliferation of hematopoietic precursors and/or in controlling cell apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
  • AK2/FADD/caspase-10 (AFAC10) complex, mediating an amplification loop that ensures the execution of the intrinsic apoptosis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RTDG
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS