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FLASH GENE
Symbol AIFM2 contributors: - updated : 23-05-2007
HGNC name apoptosis-inducing factor, mitochondrion-associated, 2
HGNC id 21411
Location 10q22.2      Physical location : 71.872.029 - 71.892.690
Synonym name
  • apoptosis-inducing factor (AIF)-like mitchondrion-associated inducer of death
  • P53-responsive gene 3
    • Synonym symbol(s) PRG3, FLJ14497, AMID
    EC.number 1.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     9 Exon(s)
    regulatory sequence Promoter
    text structure promoter containing two TP53-responsive elements
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunespleen    
    Nervousnervecranial nerve  highly
     plexus choroid   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    respiratorylungalveolar epitheliummacrophage 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY FAD-dependent oxidoreductase family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in nitric oxide detoxification and in electron
    • transport
  • mitochondria-associated protein implicated in caspase-independent apoptosis
  • oxidoreductase with a modified flavin cofactor and DNA binding activity
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
    cell & other
    REGULATION
    induced by tumor suppressor protein p53 in colon cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS