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FLASH GENE
Symbol AIFM2 contributors: - updated : 23-05-2007
HGNC name apoptosis-inducing factor, mitochondrion-associated, 2
HGNC id 21411
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen    
Nervousnervecranial nerve  highly
 plexus choroid   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
respiratorylungalveolar epitheliummacrophage 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY FAD-dependent oxidoreductase family
CATEGORY transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in nitric oxide detoxification and in electron
  • transport
  • mitochondria-associated protein implicated in caspase-independent apoptosis
  • oxidoreductase with a modified flavin cofactor and DNA binding activity
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
    cell & other
    REGULATION
    induced by tumor suppressor protein p53 in colon cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS