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Symbol AGTR1 contributors: mct - updated : 10-11-2017
HGNC name angiotensin II receptor, type 1
HGNC id 336
Corresponding disease
RTD3 renal tubular dysgenesis 3
Location 3q24      Physical location : 148.415.657 - 148.460.788
Synonym name
  • type 1B angiotensin 2 receptor
  • angiotensin receptor 1B
  • Synonym symbol(s) AGTR, AT1R, AT1A, AT1B, AT2R1, AG2S, AGTR1A, AGTR1B
    TYPE functioning gene
    STRUCTURE 45.27 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 2362 41.1 359 liver,lung,adrenal and adrenocortical adenomas 1992 1378723
    3 splicing 2336 41.1 359 liver,lung,adrenal and adrenocortical adenomas 1992 1378723
    2 splicing 2278 41.1 359 liver,lung,adrenal and adrenocortical adenomas 1992 1378723
  • pC1
  • 3 splicing 2236 41.1 359 liver, lung, adrenal and adrenocortical adenomas 1992 1378723
  • pC4
  • 4 - 2420 44.1 359 - 1992 1378723
  • pC3
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Nervousbrainbasal nucleicaudate nucleus   Homo sapiens
     brainbasal nucleistriatum   Homo sapiens
    Reproductivefemale systemplacenta    Homo sapiens
    Urinarykidney     Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel highly Homo sapiens
    Muscularstriatum    Homo sapiens
    Muscularstriatumcardiac   Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Cardiovascularendothelial cell Homo sapiens
    Digestivehepatocyte Homo sapiens
    Muscularmyocyte Homo sapiens
    Urinarymesenchymal cell
    Urinarytubular cell Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • seven transmembrane domains that provide structural support for the formation of the ligand-binding pocket
  • two distinct calmodulin binding sites within AGTR1, at juxtamembrane regions of the N-terminus of the third intracellular loop (AAs 214-231) and carboxyl tail (AA 302-317)
  • C-terminus (CT) of AGTR1 directly and strongly bound to tubulin and the binding domains were mapped to two consecutive Lys residues at positions 310 and 311 in the CT membrane-proximal region of AGTR1 and the acidic CT of tubulin
  • mono polymer heteromer , dimer
    interspecies ortholog to murine Agtr1
  • rhodopsin family
  • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • major blood pressure regulator (activation of vascular growth)
  • activating phospholipase C and A2 inhibiting adenylate cyclase
  • fundamental role for AGT/AGTR1 in age-induced vascular dysfunction
  • may play a role in the pathophysiology of ischemic heart disease and could provide important targets for pharmaceutical interventions
  • G alpha(q/11)-coupled G protein-coupled receptor, inducing membrane blebbing by coupling to RHOA, Rho kinase, and myosin light chain kinase
  • AGTR1 and AGTR2, in the striatum exert an opposite effect on the modulation of dopamine synthesis rather than dopamine release
  • AGTR1 and AGTR2 reciprocally regulate basal perfusion of muscle microvasculature
  • AGTR1 activity restrains muscle metabolic responses to insulin via decreased microvascular recruitment and insulin delivery
  • opposing effects of AGTR1 and AGTR2 on VEGF-driven angiogenesis converge on the regulation of activity of RHOA-ROCK-dependent endothelial cells migration
  • role for AGTR1 on T lymphocytes to protect the kidney in the setting of hypertension by favorably modulating CD4(+) T helper cell differentiation
  • plays a pivotal role in the development of chronic heart failure (CHF), and is upregulated in a number of tissues owing, in part, to transcription factor nuclear factor kappa B (NFKB)
  • important role of the microtubule network in the cell surface transport of AGTR1
  • may be of crucial importance for the modulation of intestinal epithelial cells apoptosis
  • has a central role in the regulation of blood pressure
  • AGTR1 and APLNR are mechanosensitive GPCRs in the heart, playing vital roles in cardiac physiological adaptation to changes in mechanical load
    signaling hormonal
    a component
  • AGTR1–APLNR heterodimers activate distinct signaling pathways compared to monomeric receptors, or the multiple reported downstream pathways of AGTR1 and APLNR may be partially dependent on the activation of the heterodimeric receptor
    small molecule
  • interaction with DRD5 (mediates AGTR1 degradation via a ubiquitin-proteasome pathway)
  • ARAP1 may serve as a local modulator of vascular AGTR1 function
  • AGTRAP is a molecule specifically interacting with the carboxyl- terminal domain of AGTR1
  • stimulation of the AGTR1 on catecholaminergic cells is required for the full development of angiotensin-dependent hypertension
  • GRK4, via regulation of arterial AGTR1 expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension
  • NFKB and CREB1 are required for angiotensin II type 1 (AGTR1) receptor upregulation in neurons
  • SND1 increases angiotensin II type 1 receptor (AGTR1) levels by increasing AGTR1 mRNA stability
  • regulatory role of DRD4 on AGTR1 expression and function in in the vascular smooth muscle cell (VSMC)
  • AGTR2 inhibits ligand-induced AGTR1 signaling through the PKC-dependent pathway
  • AGTR1 is an ouabain-associating protein
  • IRF1 is one of the key transcriptional factors for the prevention of neointimal formation involving AGTR1, AGTR2
  • dysregulated (RGS5-mediated) AGTR1 signaling could likely contribute to excessive vasoconstriction in hypertension
  • AGT regulates ARHGDIA stability by SUMOylation and ubiquitination via AT1R activation and thus affects VSMC proliferation and vascular remodeling
  • cell & other
    activated by increased circulating AGT (this acivations are important mediators in the pathophysiology of several diseases characterized by sympatho-excitation)
    repressed by SIRT1 (downregulates AGTR1 expression in vascular smooth muscle cells)
    corresponding disease(s) RTD3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in benign prostatic hyperplasia
    tumoral     --other  
    AGT plays a role in the growth of AGTR1-positive breast cancer cells through PI3-kinase/Akt pathway activation
    constitutional       gain of function
    of EDNRB and AGTR1 in vascular smooth muscle cells in ischemic heart disease
    constitutional     --other  
    altered expression of AGTR1 and AGTR2 with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration
  • contributing in association with ACE to the risk of coronary disease, to diabetic nephropathy and essential hypertension
  • to development of retinopathy of prematurity (ROP)
  • to fetal growth restriction syndrome
  • to pediatric hypertrophic cardiomyopathy with poor outcome
  • Variant & Polymorphism SNP , repeat , other
  • increasing the risk of fetal growth restriction syndrome
  • associated with progressive septal hypertrophy and left ventricular outflow tract obstruction in children with hypertrophic cardiomyopathy
  • association between SNPs and the development of ROP
  • Candidate gene
    Therapy target
  • therapy for hypertension might be optimized by designing compounds that can target the AGTR1 and DRD5
  • targeting AGT/AGTR1 signaling could be a novel therapeutic for breast cancer