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Symbol AGTR1 contributors: mct - updated : 10-11-2017
HGNC name angiotensin II receptor, type 1
HGNC id 336
corresponding disease(s) RTD3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in benign prostatic hyperplasia
tumoral     --other  
AGT plays a role in the growth of AGTR1-positive breast cancer cells through PI3-kinase/Akt pathway activation
constitutional       gain of function
of EDNRB and AGTR1 in vascular smooth muscle cells in ischemic heart disease
constitutional     --other  
altered expression of AGTR1 and AGTR2 with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration
  • contributing in association with ACE to the risk of coronary disease, to diabetic nephropathy and essential hypertension
  • to development of retinopathy of prematurity (ROP)
  • to fetal growth restriction syndrome
  • to pediatric hypertrophic cardiomyopathy with poor outcome
  • Variant & Polymorphism SNP , repeat , other
  • increasing the risk of fetal growth restriction syndrome
  • associated with progressive septal hypertrophy and left ventricular outflow tract obstruction in children with hypertrophic cardiomyopathy
  • association between SNPs and the development of ROP
  • Candidate gene
    Therapy target
  • therapy for hypertension might be optimized by designing compounds that can target the AGTR1 and DRD5
  • targeting AGT/AGTR1 signaling could be a novel therapeutic for breast cancer