| basic FUNCTION
| mediating amyloid beta peptide effect on neurons and microglia and mediating the amyloid -beta peptide transport across the blood -brain barrier and accumulation in brain |
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playing distinct functional roles in both the toxicity and disposal of advanced glycation end products (AGEs), substances that are linked to diabetes and aging |
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may play an important role in inflammatory processes and endothelial activation, likely to accelerate the processes of coronary atherosclerotic development, especially in diabetic patients |
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play an important role in the internalization of Mycobacterium tuberculosis into macrophages  |
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mediates responses to cell danger and stress |
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RAGE activates programs responsible for acute and chronic inflammation, when bound by its many ligands |
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implicated as a pro-inflammatory factor in chronic inflammatory conditions such as diabetes mellitus and rheumatoid arthritis |
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plays an important role in the development and progression of vascular disease |
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together with caspase-3 activation and inhibition of NF-kappaB signaling pathways, might be involved in the pathogenesis of macrophage apoptosis induced by HMGB1 |
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contributes to the inflammatory response in many acute and chronic diseases |
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AGER and ICAM1 are a new set of functionally linked adhesion molecules, which closely cooperate in mediating leukocyte adhesion during the acute trauma-induced inflammatory response |
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induces the expression of thioredoxin interacting protein (TXNIP) in Schwann cells and the injured sciatic nerve) |
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AGER and ICAM1 differentially regulate leukocyte adhesion in a stimulus-dependent manner |
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prominent role in the survival and development of prostate tumor growth |
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is required for the activation of interleukin 6 (IL6)–mediated mitochondrial signal transducers and activators of transcription 3 (STAT3) signaling in pancreatic carcinogenesis |
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is required for the mitochondrial localization of STAT3 in pancreatic cancer cells |
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AGER-mediated autophagy is required for enhanced ATP production and proliferation in pancreatic cancer cells, mostly via regulation of mitochondrial STAT3 |
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expression of AGER on adaptive immune cells and a role for this receptor and its ligands in modulating human immune responses |
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RETN, S100A12 and AGER are involved in the pathophysiology of Kawasaki disease (KD) |
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novel roles for AGER as a conduit for LPA (phospholipid lysophosphatidic acid) signaling |
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key molecule in the onset and sustainment of the inflammatory response |
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expression in keratinocytes is critically involved in the perpetuation of acute inflammation, supporting the central role of AGER in paracrine communication between keratinocytes and stromal immune cells |
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major receptor that mediates vascular inflammation |
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AGER-heparan sulfate oligomeric complexes are essential for signaling and interfering with AGER oligomerization might be of therapeutic value |
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is an inflammation perpetuating multi-ligand receptor and participates actively in various vascular and inflammatory diseases even in normoglycaemic conditions |
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is a multifunctional receptor implicated in diverse processes including inflammation and cancer |
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functional role for AGER/S100A7 signaling in linking inflammation to aggressive breast cancer development |
