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FLASH GENE
Symbol AGER contributors: mct - updated : 18-06-2015
HGNC name advanced glycosylation end product-specific receptor
HGNC id 320
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in cerebral vasculature of Alzheimer's disease patients
constitutional     --over  
increased in preeclampsia (Fasshauer 2008)
constitutional     --over  
in patients with pulmonary tuberculosis as well as in diabetics
constitutional       gain of function
implicated in numerous pathological states including vascular disease, diabetes, cancer, and neurodegeneration
Susceptibility to type 1 diabetes
Variant & Polymorphism SNP , other -374 T/A polymorphism associated to type 1 diabetes
Candidate gene
Marker
  • CCNB2, AGER, CDK5RAP3, may be used as a very reliable biomarker of lung adenocarcinoma
  • mRNA expression of S100A12 and AGER might be as a useful biomarker for Transitional cell carcinoma (TCC)
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousvascular 
    therapeutic intervention targeted at the AGER gene may be a useful means of treating pathologies of the vasculature
    neurologyneurodegenerativealzheimer
    pharmacological stimulation of AGER shedding might open alternative treatment strategies for Alzheimer disease
    diabete  
    pharmacological stimulation of AGER shedding might open alternative treatment strategies for diabetes-induced inflammation
    cardiovascularaquired 
    therapeutic antagonism of RAGE might be a unique target for therapeutic intervention in heart failure
    ANIMAL & CELL MODELS
  • Rage-deficient mice displayed a reduced propensity for breast tumor growth