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FLASH GENE
Symbol ADRA1A contributors: mct/ - updated : 13-06-2014
HGNC name adrenergic, alpha-1A-, receptor
HGNC id 277
Location 8p21.2      Physical location : 26.605.666 - 26.722.922
Synonym name
  • alpha-adrenergic receptor 1c
  • G protein coupled receptor
  • Synonym symbol(s) ADRA1C, ADRA1L1, ALPHA1AAR, ADRA1D
    DNA
    TYPE functioning gene
    STRUCTURE 117.26 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure SP1 binding sites and putative regulatory element for binding of c-AMP element response binding protein (CREB)
    MAPPING cloned Y linked N status provisional
    Physical map
    ADAM7 8p21.2 a disintegrin and metalloproteinase domain 7 NEF3 8p22-p21 neurofilament 3 (150kDa medium) NEFL 8p21 neurofilament, light polypeptide 68kDa LOC286061 8p21.2 hypothetical protein LOC286061 DOCK5 8p21.2 dedicator of cytokinesis 5 GNRH1 8p21-p12 gonadotropin-releasing hormone 1 (leutinizing-releasing hormone) KCTD9 8p21.1 potassium channel tetramerisation domain containing 9 CDCA2 8p12-21 cell division cycle associated 2 EBF2 8p21.1 early B-cell factor 2 PPP2R2A 8p21.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform LOC157489 8p21.1 similar to hypothetical protein FLJ10498 BNIP3L 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like PNMA2 8p21.1 paraneoplastic antigen MA2 LOC338097 8p21 proteasome activator subunit 2 pseudogene DPYSL2 8p21 dihydropyrimidinase-like 2 ADRA1A 8p21-p11.2 adrenergic, alpha-1A-, receptor LOC286129 8p21.1 similar to chromosome 15 open reading frame 2 STMN4 8P21.1 stathmin-like 4 TRIM35 8p21.1 tripartite motif-containing 35 PTK2B 8p21.1 PTK2B protein tyrosine kinase 2 beta CHRNA2 8p21 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) EPHX2 8p21-p12 epoxide hydrolase 2, cytoplasmic GULOP 8p21.1 gulonolactone (L-) oxidase pseudogene CLU 8p21.3-p12 clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) SCARA3 8p21 scavenger receptor class A, member 3 FLJ10853 8p21.1 hypothetical protein FLJ10853 LOC157570 8p21.1 hypothetical protein LOC157570 TOPK 8p21.2 hypothetical protein LOC157570 MGC45780 8p21.1 hypothetical protein MGC45780 LOC389643 8 hypothetical gene supported by AK129923 ELP3 8p21.1 elongation protein 3 homolog (S. cerevisiae) LOC389644 8 similar to 60S ribosomal protein L5 LOC346848 8p21.1 similar to 60S RIBOSOMAL PROTEIN L5 PNOC 8p21 prepronociceptin DKFZp434K1210 8p21.1 hypothetical protein DKFZp434K1210 PBF 8p21.1 papillomavirus regulatory factor PRF-1 FBXO16 8p21.1 F-box only protein 16 FZD3 8p21 frizzled homolog 3 (Drosophila) EXTL3 8p21 exostoses (multiple)-like 3 FLJ10871 8p21.1 hypothetical protein FLJ10871 FLJ21616 8p21.1 hypothetical protein FLJ21616
    RNA
    TRANSCRIPTS type messenger
    text truncated form ADRA1A1, ADRA12b, ADRA12c, ADRA13c, ADRA1A5, ADRA1A6, lacking the seventh TM segment (PMID: 10493934)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2281 51.5 466 in smooth muscle cells and epithelial cells of rhesus efferent ductules, epididymis and seminal vesicle, is the predominant variant in human prostate and other non-reproductive tissues such as heart, liver and pituitary 2008 18204069
  • also called ALPHA1C-1/ALPHA1A-1 or variant 1
  • encoding a 33 aa shorter isoform than variant 2
  • the N-terminal 423 aa of this isoform are identical to those of ALPHA1C-3/ALPH1A-3, ALPH1A-4, and variant 2
  • 3 splicing 2001 50.8 455 - 2008 18204069
  • also called ALPHA1A-4/ADRA1A2a or variant 4
  • encoding a 44 aa shorter isoform than variant 2
  • the N-terminal 423 aa of this isoform are identical to those of ALPHA1C-1/ALPHA1A, ALPHA1C-3/ALPH1A-3, and variant 2
  • 3 splicing 2089 47.5 429 - 2008 18204069
  • also called ALPHA1C-3/ALPHA1A-3/ADRA1A3a or variant 3
  • Its N-terminal 423 aa are identical to those of ALPH1A-4, ALPHA1C-1/ALPHA1A, and variant 2
  • - splicing - - 499 most abundant in prostate 2008 18204069
    also called ADRA1A4/ALPHA1C-2/ALPHA1A-2
    3 splicing 2304 52 475 - 2008 18204069
  • also called variant 2
  • Its N-terminal 423 aa are identical to those of ALPHA1C-3/ALPH1A-3, ALPH1A-4, and ALPHA1C-1/ALPHA1A
  • - - 3030 - 297 - 2008 18204069
    - - 1740 37 342 - 2008 18204069
    - - 2094 35 324 - 2008 18204069
    - - 1919 40 370 - 2008 18204069
    - - 1703 40 372 - 2008 18204069
    - - 1878 35 324 - 2008 18204069
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   highly
    Reproductivemale systemprostate    Homo sapiens
     male systemmale genital tractepididymis   Homo sapiens
     male systemseminal vesicles    Homo sapiens
     male systemtestis    Homo sapiens
    Respiratoryrespiratory tractlarynx  predominantly
    Urinaryureter     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • carboxyl-terminal Ser or Thr residues may be phosphorylated
  • three N-linked glycosylation sites in its N terminus
  • conjugated GlycoP , LipoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Adra1a
    ortholog to murine Adra1a
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • mediating G(1)-S cell-cycle arrest
  • mediating its action by association with G proteins that
  • activate a phosphatidylinositol-Ca2+ second messenger system
  • mediation of its effect by G(q) and G(11) proteins
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative regulation of cell proliferation; smooth muscle contraction
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by complex splicing mechanisms
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS