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FLASH GENE

Symbol

ADRA1A

contributors: mct/ - updated : 13-06-2015

HGNC name	adrenergic, alpha-1A-, receptor
HGNC id	277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21.2      Physical location : 26.605.666 - 26.722.922
Synonym name	alpha-adrenergic receptor 1c
	G protein coupled receptor
Synonym symbol(s)	ADRA1C, ADRA1L1, ALPHA1AAR, ADRA1D

DNA

TYPE	functioning gene
STRUCTURE	117.26 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

SP1 binding sites and putative regulatory element for binding of c-AMP element response binding protein (CREB)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	truncated form ADRA1A1, ADRA12b, ADRA12c, ADRA13c, ADRA1A5, ADRA1A6, lacking the seventh TM segment (PMID: 10493934)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000680 2 - 2281 NP_000671 51.5 466 in smooth muscle cells and epithelial cells of rhesus efferent ductules, epididymis and seminal vesicle, is the predominant variant in human prostate and other non-reproductive tissues such as heart, liver and pituitary 2008 18204069 also called ALPHA1C-1/ALPHA1A-1 or variant 1 encoding a 33 aa shorter isoform than variant 2 the N-terminal 423 aa of this isoform are identical to those of ALPHA1C-3/ALPH1A-3, ALPH1A-4, and variant 2 NM_033304 3 splicing 2001 NP_150647 50.8 455 - 2008 18204069 also called ALPHA1A-4/ADRA1A2a or variant 4 encoding a 44 aa shorter isoform than variant 2 the N-terminal 423 aa of this isoform are identical to those of ALPHA1C-1/ALPHA1A, ALPHA1C-3/ALPH1A-3, and variant 2 NM_033302 3 splicing 2089 NP_150645 47.5 429 - 2008 18204069 also called ALPHA1C-3/ALPHA1A-3/ADRA1A3a or variant 3 Its N-terminal 423 aa are identical to those of ALPH1A-4, ALPHA1C-1/ALPHA1A, and variant 2 variant 4 - splicing - isoform 4 - 499 most abundant in prostate 2008 18204069 also called ADRA1A4/ALPHA1C-2/ALPHA1A-2 NM_033303 3 splicing 2304 NP_150646 52 475 - 2008 18204069 also called variant 2 Its N-terminal 423 aa are identical to those of ALPHA1C-3/ALPH1A-3, ALPH1A-4, and ALPHA1C-1/ALPHA1A variant 5/5b - - 3030 isoform 5/5b - 297 - 2008 18204069 variant 6 - - 1740 isoform 6 37 342 - 2008 18204069 variant 2b - - 2094 isoform 2b 35 324 - 2008 18204069 variant 2c - - 1919 isoform 2c 40 370 - 2008 18204069 variant 3c - - 1703 isoform 3c 40 372 - 2008 18204069 variant 3b - - 1878 isoform 3b 35 324 - 2008 18204069

EXPRESSION

Type	restricted

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       highly Reproductive male system prostate       Homo sapiens   male system male genital tract epididymis     Homo sapiens   male system seminal vesicles       Homo sapiens   male system testis       Homo sapiens Respiratory respiratory tract larynx     predominantly Urinary ureter         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM)
	carboxyl-terminal Ser or Thr residues may be phosphorylated
	three N-linked glycosylation sites in its N terminus

conjugated

GlycoP , LipoP , PhosphoP

HOMOLOGY

interspecies	ortholog to rattus Adra1a
	ortholog to murine Adra1a

Homologene

FAMILY	G protein coupled receptor superfamily
	G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to plasma membrane

basic FUNCTION	mediating G(1)-S cell-cycle arrest
	mediating its action by association with G proteins that
	activate a phosphatidylinositol-Ca2+ second messenger system
	mediation of its effect by G(q) and G(11) proteins

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	negative regulation of cell proliferation; smooth muscle contraction

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

APLNR-enhanced response requires ADRA1A to contract vessels coordinately

cell & other

REGULATION

Other

regulated by complex splicing mechanisms

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS