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FLASH GENE
Symbol ADRA1A contributors: mct/ - updated : 13-06-2015
HGNC name adrenergic, alpha-1A-, receptor
HGNC id 277
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   highly
Reproductivemale systemprostate    Homo sapiens
 male systemmale genital tractepididymis   Homo sapiens
 male systemseminal vesicles    Homo sapiens
 male systemtestis    Homo sapiens
Respiratoryrespiratory tractlarynx  predominantly
Urinaryureter     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • carboxyl-terminal Ser or Thr residues may be phosphorylated
  • three N-linked glycosylation sites in its N terminus
  • conjugated GlycoP , LipoP , PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Adra1a
    ortholog to murine Adra1a
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • mediating G(1)-S cell-cycle arrest
  • mediating its action by association with G proteins that
  • activate a phosphatidylinositol-Ca2+ second messenger system
  • mediation of its effect by G(q) and G(11) proteins
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative regulation of cell proliferation; smooth muscle contraction
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APLNR-enhanced response requires ADRA1A to contract vessels coordinately
  • cell & other
    REGULATION
    Other regulated by complex splicing mechanisms
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS