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FLASH GENE
Symbol ADCY9 contributors: KTN - updated : 28-03-2008
HGNC name adenylate cyclase 9
HGNC id 240
Location 16p13.3      Physical location : 4.012.652 - 4.166.186
Synonym symbol(s) AC9
EC.number 4.6.1.1
DNA
TYPE functioning gene
STRUCTURE 153.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
OR1F1 16p13.3 olfactory receptor, family 1, subfamily F, member 1 OR1F2 16p13.3 olfactory receptor, family 1, subfamily F, member 2 ZNF200 16p13.3 zinc finger protein 200 MEFV 16p13.3 Mediterranean fever FLJ39639 16p13.3 hypothetical protein FLJ39639 ZNF263 16p13.3 zinc finger protein 263 TIGD7 16p13.11 tigger transposable element derived 7 ZNF75A 16p13.11 zinc finger protein 75a LOC390670 16 similar to ribosomal protein L7-like 1 OR2C1 16p13.3 olfactory receptor, family 2, subfamily C, member 1 ZNF434 16p13.3 zinc finger protein 434 ZNF174 16p13.3 zinc finger protein 174 FLJ33071 16p13.3 hypothetical protein FLJ33071 LOC388207 16 LOC388207 FLJ14154 16p13.3 hypothetical protein FLJ14154 LOC390671 16 similar to ribosomal protein L18; 60S ribosomal protein L18 KIAA0643 16p13.3 similar to ribosomal protein L18; 60S ribosomal protein L18 NOD3 16p13.3 NOD3 protein BTBD12 16p13.3 BTB (POZ) domain containing 12 LOC283877 16p13.3 hypothetical LOC283877 DNASE1 16p13.3 deoxyribonuclease I TRAP1 15q25-q26 tumor rejection antigen (gp96) pseudogene 1 CREBBP 16p13.3 CREB binding protein (Rubinstein-Taybi syndrome) ADCY9 16p13.3 adenylate cyclase 9 LOC388208 16 LOC388208 SRL 16p13.3 sarcalumenin TFAP4 16p13 transcription factor AP-4 (activating enhancer binding protein 4) GLIS2 16p13.3 Kruppel-like zinc finger protein GLIS2 Magmas 16p13.3 mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction FLJ22021 16p13.3 hypothetical protein FLJ22021 DNAJA3 16p13.3 DnaJ (Hsp40) homolog, subfamily A, member 3 HSCARG 16p13.3 HSCARG protein HMOX2 16p13.3 heme oxygenase (decycling) 2 C16orf5 16p13.3 heme oxygenase (decycling) 2 LOC342346 16p13.3 similar to hypothetical protein DKFZp434P0316 LOC124402 16p13.3 LOC124402 MGRN1 16p13 mahogunin, ring finger 1 SDOS 16p13.3 hypothetical protein MGC11275
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 7732 150 1353 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   moderately
Endocrinethyroid   moderately
Hearing/Equilibriumear   highly
Nervousbrain    
 nerve   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains
  • an Asm-linked glycosylation site
  • a cAMP-dependent protein kinase phosphorylation site
  • two guanylate cyclase domains
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to dog ADCY9 (93 pc)
    homolog to chimpanzee ADCY9 (98 pc)
    homolog to murine Adcy9 (92.2 pc)
    homolog to chicken ADCY9 (82 pc)
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylyl cyclase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
  • basic FUNCTION
  • acting as an adenylyl cyclase type IX
  • may play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function
  • may be a physiologically relevant docking site for calcineurin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
  • cAMP biosysthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+ (2 ions per subunit)
  • protein
    cell & other
    REGULATION
    activated by beta adrenergic receptor activation,agonists
    Other regulated by G protein coupled receptors,protein kinases and calcium Ca2+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS