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FLASH GENE
Symbol ADCY9 contributors: KTN - updated : 28-03-2008
HGNC name adenylate cyclase 9
HGNC id 240
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 7732 150 1353 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   moderately
Endocrinethyroid   moderately
Hearing/Equilibriumear   highly
Nervousbrain    
 nerve   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains
  • an Asm-linked glycosylation site
  • a cAMP-dependent protein kinase phosphorylation site
  • two guanylate cyclase domains
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to dog ADCY9 (93 pc)
    homolog to chimpanzee ADCY9 (98 pc)
    homolog to murine Adcy9 (92.2 pc)
    homolog to chicken ADCY9 (82 pc)
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylyl cyclase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
  • basic FUNCTION
  • acting as an adenylyl cyclase type IX
  • may play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function
  • may be a physiologically relevant docking site for calcineurin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
  • cAMP biosysthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+ (2 ions per subunit)
  • protein
    cell & other
    REGULATION
    activated by beta adrenergic receptor activation,agonists
    Other regulated by G protein coupled receptors,protein kinases and calcium Ca2+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS