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FLASH GENE
Symbol ADAMTS10 contributors: mct/npt/pgu - updated : 03-04-2018
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 10
HGNC id 13201
Corresponding disease
WMSAR Weill-Marchesani syndrome 2
Location 19p13.2      Physical location : 8.645.125 - 8.675.588
Synonym name
  • a disintegrin and metalloproteinase with thrombospondin motifs 10
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
  • Weill-Marchesani syndrome
  • zinc metalloendopeptidase
  • Synonym symbol(s) AT10, ADAM-TS10, WMS
    EC.number 3.4.24
    DNA
    TYPE functioning gene
    STRUCTURE 30.50 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC115704 19p13.3 similar to ecotropic viral integration site 5; Neuroblastoma stage 4S gene LOC388499 19 similar to lysophospholipase II; acyl-protein thioesterase FLJ23420 19p13.3 hypothetical protein FLJ23420 MAP2K7 19p13.2 mitogen-activated protein kinase kinase 7 LOC388500 19 LOC388500 SNAPC2 19q13.3-p13.2 small nuclear RNA activating complex, polypeptide 2, 45kDa TIMM44 19p13.3-p13.2 translocase of inner mitochondrial membrane 44 homolog (yeast) ELAVL1 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) CCL25 19p13.2 chemokine (C-C motif) ligand 25 FBN3 19p13 fibrillin 3 LASS4 19p13.3 LAG1 longevity assurance homolog 4 (S. cerevisiae) 8D6A 19p13.3-p13.2 LAG1 longevity assurance homolog 4 (S. cerevisiae) NDUFA7 19p13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa RPS28 19p13.2 ribosomal protein S28 FLJ46061 19p13.3 FLJ46061 protein ANGPTL4 19p13.3 angiopoietin-like 4 RAB11B 19p13.3 RAB11B, member RAS oncogene family LOC51257 19p13.3 hypothetical protein LOC51257 HNRPM 19p13.3 heterogeneous nuclear ribonucleoprotein M PRAM-1 19p13.3 PRAM-1 protein MGC15716 19p13.3 hypothetical protein MGC15716 MYO1F 19p13.3-p13.2 myosin IF ADAMTS10 19p13.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 LOC390880 19 similar to nuclear factor, interleukin 3, regulated MGC33407 19p13.2 hypothetical protein MGC33407 LOC390881 19 similar to 60S ribosomal protein L23a LOC284383 19p13.2 similar to Olfactory receptor 2Z1 FLJ30932 19p13.2 hypothetical protein FLJ30932 MBD3L1 19p13.3 methyl-CpG binding domain protein 3-like 1 LOC388501 19 hypothetical gene supported by AF414442; AK024365; AK056791; AK128856 LOC125963 19p13.2 similar to Olfactory receptor 1M1 (Olfactory receptor 19-6) (OR19-6) LOC390882 19 similar to Olfactory receptor 7G2 (Olfactory receptor 19-13) (OR19-13) (OST260) LOC125962 19p13.2 similar to Olfactory receptor 7G1 (Olfactory receptor 19-15) (OR19-15) LOC390883 19 similar to Olfactory receptor 7G3 (OST085) ZNF317 19p13 zinc finger protein 317 FLJ38149 19p13.2 hypothetical protein FLJ38149 OR7E16P 19p13.13 olfactory receptor, family 7, subfamily E, member 16 pseudogene LOC390884 19 similar to olfactory receptor MOR145-1 LOC125958 19p13.2 similar to seven transmembrane helix receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 4237 120.7 1103 - 2008 18567016
    13 - 2475 - 590 - 2008 18567016
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Endocrinethyroid   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, liver, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one propeptide region
  • one metalloproteinase domain
  • one disintegrin-like domain
  • five thrombospondin type 1 (TS) motif
  • one cysteine-rich and one cysteine-poor domains
  • a cysteine-rich PLAC (protease and lacunin) domain and ancillary domain at the carboxyl terminus
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine At10
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a major role in growth and in skin, lens, and heart development
  • could play a role in connective tissue remodeling
  • participates in microfibril biogenesis rather than in fibrillin-1 turnover
  • participates likely in sperm adhesion to the zona pellucida
  • is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition
  • ADAMTS10 and ADAMTS6 oppositely affect heparan sulphate-rich interfaces including focal adhesions
  • novel role for the metalloprotease ADAMTS10 in the pituitary
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ADAMTS10 binds to fibrillin-1
  • ability of IKZF1 to bind the ADAMTS10 promoter, influencing its transfected activity, and inducing endogenous gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WMSAR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS