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FLASH GENE
Symbol ADAMTS10 contributors: mct/npt/pgu - updated : 03-04-2018
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 10
HGNC id 13201
DNA
TYPE functioning gene
STRUCTURE 30.50 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 4237 120.7 1103 - 2008 18567016
13 - 2475 - 590 - 2008 18567016
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Endocrinethyroid   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
Visualeyelens   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lung, liver, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one propeptide region
  • one metalloproteinase domain
  • one disintegrin-like domain
  • five thrombospondin type 1 (TS) motif
  • one cysteine-rich and one cysteine-poor domains
  • a cysteine-rich PLAC (protease and lacunin) domain and ancillary domain at the carboxyl terminus
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine At10
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a major role in growth and in skin, lens, and heart development
  • could play a role in connective tissue remodeling
  • participates in microfibril biogenesis rather than in fibrillin-1 turnover
  • participates likely in sperm adhesion to the zona pellucida
  • is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition
  • ADAMTS10 and ADAMTS6 oppositely affect heparan sulphate-rich interfaces including focal adhesions
  • novel role for the metalloprotease ADAMTS10 in the pituitary
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ADAMTS10 binds to fibrillin-1
  • ability of IKZF1 to bind the ADAMTS10 promoter, influencing its transfected activity, and inducing endogenous gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WMSAR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS