motifs/domains
| a signal peptide (5,1 kDa) |
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a propeptide domain |
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a reprolysin-type catalytic domain |
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two disintegrin loops, a disintegrin-like domain showed no structural homology to the disintegrin domains of other metalloproteinases such as ADAM10 but is instead very similar in structure to the cysteine-rich domains of other metalloproteinases (Gerhardt 2007) |
|
a thrombospondin type 1 (TSP1) module |
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a cysteine rich domain, a spacer domain without cysteine residues, stacking against the active site, suggesting a possible regulatory role (Gerhardt 2007) |
|
three C-terminal TSP-like modules, TSP type I motifs and the spacer region responsible for its experimental metastasis-inhibitory activity |
| basic FUNCTION
| cell surface adhesion protein, involved in mineralised nodule and bone formation |
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inflammation-induced gene inhibiting endothelial cell proliferation |
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may be implicated in cell migration in retina and in inflammatory eye diseases |
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blocking KDR phosphorylation with consequent suppression of endothelial cell proliferation |
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having anti-angiogenic activity |
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playing an important role for follicular development and involved in the organization of the medullary vascular network |
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capable of binding to and degrading extracellular matrix components (Lu 2009) |
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promotes tumor development through the induction of a stromal reaction (Rocks 2008) |
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involved in tissue remodelling, wound healing and angiogenesis (Gerhardt 2007) |
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inducing the cleavage of SEMA3C and promoting the migration of breast cancer cells, thus contributing to the metastatic program (Esselens 2010) |
