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Symbol ADAMTS1 contributors: mct - updated : 25-09-2018
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 1
HGNC id 217
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
associated with various inflammatory processes as well as development of cancer cachexia
constitutional     --over  
in brain of patients with neurodegenerative disease leading to or reflecting pathological lesions in Down syndrome
tumoral       loss of function
ADAMTS1 gene inactivated through promoter hypermethylation in colorectal tumor development
strongly expressed in myocardial infarction (Hatipoglu 2009)
tumoral     --over  
promotes pulmonary metastasis of TA3 mammary carcinoma (Lu 2009)
tumoral     --low  
by aberrant methylation of ADAMTS1 in non-small cell lung cancer (Choi 2008)
constitutional     --low  
in the maternal and cord blood were lower in the preeclampsia group than in the control group
Variant & Polymorphism
Candidate gene
  • may be used as marker protein for neurodegeneration
  • molecular targeting of MMP1 and ADAMTS1, combined with inhibition of EGFR, may potentially reduce the risk of bone metastasis for a significant number of breast cancer patients (Lu 2009)
  • Marker
  • methylation status of ADAMTS1 and BNC1 in cfDNA shows promise for detecting pancreatic cancer during the early stages when curative resection of the tumor is still possible
  • Therapy target