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FLASH GENE
Symbol ADAM9 contributors: mct/pgu - updated : 30-01-2013
HGNC name ADAM metallopeptidase domain 9 (meltrin gamma)
HGNC id 216
Corresponding disease
CORD12 cone-rod dystrophy type 12
Location 8p11.23      Physical location : 38.854.504 - 38.962.777
Synonym name
  • meltrin gamma
  • myeloma cell metalloproteinase
  • a disintegrin and metalloproteinase domain 9 (meltrin gamma)
  • cellular disintegrin-related protein
  • Synonym symbol(s) KIAA0021, MLTNG, MCMP, MDC9
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 108.27 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D8S505 - D8S283 - D8S1722 -D8S536 - ADAM9 - INDO - D8S255 - D8S1817 - D8S268 - D8S532 - D8S519 - cen
    Authors Gene Map (98)
    Physical map
    LOC392213 8 similar to SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; BAF57 LOC389647 8 LOC389647 LOC389648 8 LOC389648 FLJ14299 8p11.23 hypothetical protein FLJ14299 C8orf2 8p11.2 chromosome 8 open reading frame 2 PROSC 8p11.2 proline synthetase co-transcribed homolog (bacterial) GPR124 8p11.23 G protein-coupled receptor 124 BRF2 8q11.23 BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like RCP 8p11.22 Rab coupling protein MGC33309 8p11.23 hypothetical protein MGC33309 ASH2L 8p11.2 ash2 (absent, small, or homeotic)-like (Drosophila) STAR 8p11.2 steroidogenic acute regulatory protein LSM1 8p11.2 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) BAG4 8p11.23 BCL2-associated athanogene 4 KIAA0725 8p11.22 BCL2-associated athanogene 4 HTPAP 8p11.23 HTPAP protein WHSC1L1 8p12-p11.2 Wolf-Hirschhorn syndrome candidate 1-like 1 FLJ25409 8p11.22 hypothetical protein FLJ25409 FGFR1 8p12 fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) LOC389649 8 hypothetical gene supported by AK125570 LOC286140 8p11.22 similar to ring finger protein 5 TACC1 8p11 transforming, acidic coiled-coil containing protein 1 PLEKHA2 8p11.21 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 FLJ90724 8p11.22 hypothetical protein FLJ90724 BLP1 8p11.22 BBP-like protein 1 ADAM9 8p12 a disintegrin and metalloproteinase domain 9 (meltrin gamma) ADAM32 8p11.22 a disintegrin and metalloprotease domain 32 ADAM5 8p11.22 a disintegrin and metalloproteinase domain 5 ADAM3A 8p21-p12 a disintegrin and metalloproteinase domain 3a (cyritestin 1) ADAM18 8p11.21 a disintegrin and metalloproteinase domain 18 ADAM2 8p11.2 a disintegrin and metalloproteinase domain 2 (fertilin beta) INDO 8p11.2 indoleamine-pyrrole 2,3 dioxygenase LOC169355 8p11.22 hypothetical protein LOC169355 C8orf4 8p11.2 chromosome 8 open reading frame 4 FLJ13842 8p11.21 hypothetical protein FLJ13842
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4111 87.6 819 widely, and in the breast carcinomas at higher levels in node-positive than node-negative cancers 2004 15205330
  • membrane protein, ADAM9L
  • suppresses cell migration independent of its metalloproteinase activity
  • 21 - 4005 69.4 655 liver, heart, both ADAM9 isoforms are expressed in breast cancer cell lines and tissues 2004 15205330
  • extracellular isoform, ADAM9S
  • has an alpha-secretase activity for APP
  • promotes breast cancer cell migration in a manner requiring its metalloproteinase activity
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines myeloma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • N-terminal prodomain
  • a disrupted Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane domain
  • a cytoplasmic tail containing two proline-rich sequences, which may bind SH3
  • conjugated GlycoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Adam9 (86.3pc)
    homolog to rattus Adam9 (85.3pc)
    intraspecies homolog to ADAM12
    Homologene
    FAMILY
  • a disintegrin and metalloprotease domain (ADAM) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in cell-cell fusion, intracellular signaling, and other cellular functions
  • involved in cell migration and invasion
  • contributing to heart development
  • functioning as cell adhesion molecule via its disintegrin-cysteine-rich domain
  • playing a role in regulating the motility of cells and modulating MMP synthesis
  • play important roles in pathological retinal neovascularization, and in the development of pathological vessels in the retina and choroid
  • modulates cell-cell and cell-matrix interactions as well as ectodomain shedding of cell surface receptors and ligands
  • ADAM9 expression plays an important role in mediating cell-cell contacts between fibroblasts and melanoma cells and these interactions contribute to proteolytic activities required during invasion of melanoma cells
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • MMP14 forms a complex with FGFR2 and ADAM9 in osteoblasts
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • one zinc Zn2+ ion per subunit
  • protein
  • binding to SH3 domain containing proteins such as SNX9, SH3GL2
  • binding to MAD2L2
  • binding to integrin alpha (V) beta (5) (to function as an adhesion molecule)
  • interacting with the beta1 integrin subunit on keratinocytes
  • involved in proteolysis of ADAM10 with ADAM15 and the gamma secretase complex
  • ADAM10 activity is regulated by inhibition of ADAM9, and this regulation may be used to control shedding of amyloid precursor protein by enhancing alpha-secretase activity, a key regulatory step in the etiology of Alzheimer disease
  • generally specific inhibition of ADAM9 controls membrane ADAM10 activity, which could be of general relevance
  • requirement for ADAM9 in lipopolysaccharide induced ACE shedding
  • MMP14 inactivates ADAM9, hence protecting FGFR2 from ADAM9-mediated ectodomain shedding on the cell surface
  • cell & other
  • cell-cell and cell-matrix interactions
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORD12
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma, node-positive
    tumoral     --over  
    in non-small cell lung cancer correlates with brain metastasis
    tumoral     --over  
    in gastric carcinoma, and pancreatic cancer
    Susceptibility to sporadic Alzheimer disease (SAD)
    Variant & Polymorphism other
  • promoter polymorphisms which regulate ADAM9 transcription are protective against SAD
  • Candidate gene
  • may be a valid target for gene therapy (Parry 2009)
  • attractive target for the prevention of proliferative retinopathies, choroidal neovascularization, and cancer
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • overexpressed in breast carcinoma, node-positive
  • progressive degeneration affecting both rods and cones in Adam9−/− mice