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FLASH GENE

Symbol

ADAM9

contributors: mct/pgu - updated : 30-01-2017

HGNC name	ADAM metallopeptidase domain 9 (meltrin gamma)
HGNC id	216

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CORD12

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinoma, node-positive tumoral     --over   in non-small cell lung cancer correlates with brain metastasis tumoral     --over   in gastric carcinoma, and pancreatic cancer

Susceptibility

to sporadic Alzheimer disease (SAD)

Variant & Polymorphism other	promoter polymorphisms which regulate ADAM9 transcription are protective against SAD

Candidate gene	may be a valid target for gene therapy (Parry 2009)
	attractive target for the prevention of proliferative retinopathies, choroidal neovascularization, and cancer
Marker
Therapy target

ANIMAL & CELL MODELS

	overexpressed in breast carcinoma, node-positive
	progressive degeneration affecting both rods and cones in Adam9−/− mice