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FLASH GENE
Symbol ADAM9 contributors: mct/pgu - updated : 30-01-2013
HGNC name ADAM metallopeptidase domain 9 (meltrin gamma)
HGNC id 216
ASSOCIATED DISORDERS
corresponding disease(s) CORD12
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast carcinoma, node-positive
tumoral     --over  
in non-small cell lung cancer correlates with brain metastasis
tumoral     --over  
in gastric carcinoma, and pancreatic cancer
Susceptibility to sporadic Alzheimer disease (SAD)
Variant & Polymorphism other
  • promoter polymorphisms which regulate ADAM9 transcription are protective against SAD
  • Candidate gene
  • may be a valid target for gene therapy (Parry 2009)
  • attractive target for the prevention of proliferative retinopathies, choroidal neovascularization, and cancer
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • overexpressed in breast carcinoma, node-positive
  • progressive degeneration affecting both rods and cones in Adam9−/− mice