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FLASH GENE
Symbol ADAM19 contributors: mct - updated : 28-01-2012
HGNC name ADAM metallopeptidase domain 19 (meltrin beta)
HGNC id 197
Location 5q33.3      Physical location : 156.904.312 - 157.002.783
Synonym name
  • a disintegrin and metalloproteinase domain 19 (meltrin beta)
  • meltrin-beta
  • metalloprotease and disintegrin dendritic antigen marker
    • Synonym symbol(s) MLTNB, FKSG34, MADDAM
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 98.47 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure putative binding sites for several transcription factors including Sp1, Sp3, NF-kappaB, and VDR
    MAPPING cloned Y linked Y status provisional
    Map cen - D5S487 - [D5S2112 ,ADAM19 ] - D5S2525 - D5S512 - qter
    Authors Hirohata (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3127 105 956 - 2001 11162584
    23 splicing 6506 101 918 - 2001 11162584
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemplacenta  highly Homo sapiens
    Respiratorylung   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines colorectal adenocarcinoma cells
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text
  • placenta, high expression during nephrogenesis pointing to a role in growth promotion and regulation
  • widely distributed in villous cytotrophoblast cells, syncytiotrophoblast cells, column trophoblasts, and villous capillary endothelial cells during early pregnancy (PMID :
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP) with a prodomain
  • a Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane domain
  • a cytoplasmic tail
  • one disintegrin domain
    • conjugated GlycoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Mltnb
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
    • CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • expressed in the Golgi
    • basic FUNCTION
  • involved in myotube formation and osteoblast differentiation and /or osteoblast activity in bone
  • playing a role in the processing of neuregulin
  • contribute to heart development
  • may play a significant role in tumor invasion that may be detrimental to patients survival
  • has a constitutive alpha-secretase activity for APP
  • plays crucial roles in nerve regeneration after a crush injury to the sciatic nerves
  • role in Schwann cell differentiation and re-myelination in nerve regeneration
  • functions as a modulator of juxtacrine signaling from axons that activate the Akt pathway and the EGR2 expression, which is the prerequisite for Schwann cell differentiation
  • may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation
    • CELLULAR PROCESS protein, degradation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha 2-M
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
    • protein
  • CRIP2 associated with ADAM19 through its disintegrin (DI) domain, and cysteine-rich (Cys) domains (ADAM19 promotes the secretion of CRIP2)
  • one of cleaving proteases of ATP6AP2 (ATP6AP2 is cleaved by ADAM19 in the Golgi resulting in two fragments, N-terminal and C-terminal fragment)
    • cell & other
  • cell-cell and cell matrix interaction
    • REGULATION
    Other important role of histone acetylation in the regulation of ADAM19
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increasing tubular ADAM19 associated with declining renal function
    tumoral     --other  
    epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Meltrin-beta-deficient mice exhibited delayed sciatic functional recovery after the nerve crush