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FLASH GENE
Symbol ACSM2A contributors: KTN/npt - updated : 25-06-2008
HGNC name acyl-CoA synthetase medium-chain family member 2A
HGNC id 32017
Location 16p12.3      Physical location : 20.462.858 - 20.498.989
Synonym name
  • acyl-coenzyme A synthetase ACSM2A, mitochondrial
  • butyryl coenzyme A synthetase 2A
  • middle-chain acyl-CoA synthetase 2A
  • homolog of rat kidney-specific (KS)
    • Synonym symbol(s) A-923A4.1, MGC150530, ACSM2, MACS2
    EC.number 6.2.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 36.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2969 64 577 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunetonsils   moderately
    Reproductivefemale systembreastmammary gland moderately
    Urinarykidney   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to dog ACSM2A (79 pc)
    homolog to murine Acsm2a (76.3 pc)
    Homologene
    FAMILY
  • ATP-dependent AMP-binding enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acting as a medium-chain fatty acid : CoA ligase
  • acting on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • fatty acid and lipid metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • Mg2+
  • Mn2+
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS