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FLASH GENE
Symbol ACSL5 contributors: mct - updated : 04-09-2018
HGNC name acyl-CoA synthetase long-chain family member 5
HGNC id 16526
Location 10q25.2      Physical location : 114.133.915 - 114.188.137
Synonym name
  • long-chain acyl-COA synthetase 5
  • fatty-acid-Coenzyme A ligase, long-chain 5
    • Synonym symbol(s) ACS2, ACS5, FACL5
    EC.number 6.2.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 54.22 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 splicing 3233 76 683 - Yamashita
    21 splicing 3372 - 739 - Yamashita
    21 - 3399 - 683 . 683aa ACSL5 isoform, localized mainly in the mitochondria, -
  • playing a greater role in fatty acid oxidation
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveintestinesmall intestine    Homo sapiens
    Reproductivefemale systemuterus  highly
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum spinosum  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte Homo sapiens
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Facl5
    Homologene
    FAMILY
  • long-chain fatty-acid coenzyme A ligase family
  • ATP-dependent AMP-binding enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • converting free long-chain fatty acids into fatty acyl CoA esters
  • functioning in mediating fatty acids-induced glioma cell growth
  • utilizing a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids
  • epidermal ACSL5 expression might be involved in differentiation and the stress response of keratinocytes
  • critical to the expression of tumor-related factors including midkine (MDK), a heparin-binding growth factor frequently overexpressed in cancer
  • is an important branch point in hepatic fatty acids (FAs) metabolism
  • may play a role in the apoptosis that takes place in systemic lupus erythematosus
  • catalyzes the synthesis of long-chain fatty acid thioesters and is physiologically involved in pro-apoptotic sensing of enterocytes
  • mediates antiproliferative activities via WNT2B palmitoylation with diminished Wnt activity
  • is involved in enterocytic differentiation and maturation by regulating both pro-apoptotic and anti-proliferative effects
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
    • protein
  • ACSL5-induced mitochondrial HSPA9 expression is assumed to be a stress response to ACSL5-related changes in lipid metabolism and is regulated by the TP53 status
  • in the presence of ACSL5, WNT2B was unable to translocate into the nucleus and was enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer in patients with excess muscular layer and with poor tumor differentiation
    tumoral     --over  
    frequently overexpressed in malignant glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be an independent prognostic factor for early recurrence of sporadic colorectal adenocarcinoma
  • is a potential novel functional marker of systemic lupus erythematosus (SLE)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential target for CRC gene therapy
    immunologyautoimmuneLupus
    possible therapeutic target in SLE
    ANIMAL & CELL MODELS