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FLASH GENE
Symbol ACSL5 contributors: mct - updated : 04-09-2018
HGNC name acyl-CoA synthetase long-chain family member 5
HGNC id 16526
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveintestinesmall intestine    Homo sapiens
Reproductivefemale systemuterus  highly
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermisstratum spinosum  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveenterocyte Homo sapiens
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Facl5
Homologene
FAMILY
  • long-chain fatty-acid coenzyme A ligase family
  • ATP-dependent AMP-binding enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • converting free long-chain fatty acids into fatty acyl CoA esters
  • functioning in mediating fatty acids-induced glioma cell growth
  • utilizing a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids
  • epidermal ACSL5 expression might be involved in differentiation and the stress response of keratinocytes
  • critical to the expression of tumor-related factors including midkine (MDK), a heparin-binding growth factor frequently overexpressed in cancer
  • is an important branch point in hepatic fatty acids (FAs) metabolism
  • may play a role in the apoptosis that takes place in systemic lupus erythematosus
  • catalyzes the synthesis of long-chain fatty acid thioesters and is physiologically involved in pro-apoptotic sensing of enterocytes
  • mediates antiproliferative activities via WNT2B palmitoylation with diminished Wnt activity
  • is involved in enterocytic differentiation and maturation by regulating both pro-apoptotic and anti-proliferative effects
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
  • ACSL5-induced mitochondrial HSPA9 expression is assumed to be a stress response to ACSL5-related changes in lipid metabolism and is regulated by the TP53 status
  • in the presence of ACSL5, WNT2B was unable to translocate into the nucleus and was enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer in patients with excess muscular layer and with poor tumor differentiation
    tumoral     --over  
    frequently overexpressed in malignant glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be an independent prognostic factor for early recurrence of sporadic colorectal adenocarcinoma
  • is a potential novel functional marker of systemic lupus erythematosus (SLE)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential target for CRC gene therapy
    immunologyautoimmuneLupus
    possible therapeutic target in SLE
    ANIMAL & CELL MODELS